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NCT Number: NCT07312994

Analysis of NfL and GFAP in Different Dietary Patterns

This observational study aims to investigate the impact of different dietary patterns on brain tissue biomarkers in healthy young adults by measuring blood levels of NfL and GFAP.

The primary research question is: Do vegan, vegetarian, or omnivorous diets influence NfL and GFAP levels?

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Key information

Conditions

Neurofilament Light Chain Charcot-Marie-Tooth disease, Type 1F GFAP Glial Fibrillary Acidic Protein Vegan Diet Vegetarian Diet

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Christian-Doppler-Klinik

Salzburg, State of Salzburg, 5020, Austria

Location status: Recruiting

Location contact

Fabio Rossini, MD

CONTACT

[email protected]

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy individuals who have followed a vegan, vegetarian, or omnivorous diet for at least one consecutive year
  • Aged between 18 and 40 years
  • Provision of written informed consent

Exclusion criteria

  • Diagnose neurological disorders (e.g. neurodegenerative, inflammatory, autoimmune, infectious, vascular)
  • Eating disorders
  • Excessive alcohol consumption
  • Pregnancy
  • Recent moderate to severe infection (within the past 12 weeks) , including SARS-CoV-2
  • Recent trauma, injury, or surgery (within the past 12 weeks)
  • Significant BMI fluctuations (>5 points) within the last year
  • Patients who have been using Proton pump inhibitors (PPIs) for an extended period (e.g., 1 month).

Treatment and study plan

Primary outcomes

  1. Blood levels of the following biomarkers: neurofilament light chain (NfL) in pg/mL, glial fibrillary acidic protein (GFAP) in pg/mL.

    Time frame: Once at baseline

Study contacts

Contact information is provided by the study sponsor or research team.

Tobias Moser, Prof.

CONTACT

[email protected]

+435725534720

Sponsors and collaborators

Lead sponsor

Salzburger Landeskliniken

Other

Collaborators

  • Medizinische Einrichtungen der Universität Düsseldorf
  • Medizinische Fakultät der Universität zu Köln
  • Universitätsklinkum Münster - Medizinische Klinik und Poliklinik B

Registry information

Official study title

Vegan, Vegeratian, or Omnivore: Dietary Effects on the Brain Tissue Biomarkers

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Dec 31, 2025
Registry last updated
Dec 31, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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