Analysis of Influencing Factors for the Development of PTSD in Emergency Department Trauma Patients

The goal of this observational study is to learn about the long-term effects of key factors such as cognitive flexibility, social support, and physiological stress on the occurrence of Post-Traumatic Stress Disorder (PTSD) in adult trauma patients treated in the emergency department. The main question it aims to answer is:

Among emergency department patients who have experienced major trauma, can factors such as early post-trauma cognitive flexibility, level of social support, inflammatory markers, and trauma severity predict the development of PTSD within 6 months? Participants will complete a series of online questionnaires and clinical assessments at baseline, 1 month, 3 months, and 6 months after the traumatic event.

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Key information

Conditions

Trauma Patients Mental Disorders PTSD Stress Disorders, Post-Traumatic Stress Disorders, Traumatic Trauma and Stressor Related Disorders

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age between 18 and 65 years old (inclusive);
Experienced a life-threatening major traumatic event, clearly diagnosed by a clinician;
The patient is able to communicate normally with medical staff through language;
The subject is fully informed and voluntarily signs the informed consent form.

Exclusion criteria

History of psychiatric disorders or current use of psychotropic medications;
Pre-existing cognitive impairment (e.g., dementia, Alzheimer's disease);
Terminal illnesses (such as advanced malignant tumors, end-stage organ failure, advanced neurological diseases, or any other condition judged by the attending physician to have a life expectancy of less than 6 months);
Inability to cooperate with follow-up.

Treatment and study plan

Primary outcomes

PTSD Incidence as Assessed by the PTSD Checklist for DSM-5 (PCL-5)

Time frame: 6 months post-trauma

Number of participants with a total score ≥33 on the PCL-5 (range 0-80, higher scores indicate more severe PTSD symptoms) at 6 months after the traumatic event, indicating probable post-traumatic stress disorder (PTSD).

Secondary outcomes

Association of Sociodemographic, Trauma-Related, and Psychosocial Factors with PTSD Status

Time frame: Baselin and 6 months post-trauma

Odds ratios (ORs) and 95% confidence intervals for the association of each candidate factor (e.g., age, sex, injury severity score [ISS], social support [SSRS score], anxiety/depression [HADS score], cognitive flexibility [CFI score], inflammatory biomarkers [IL-6, CRP]) with probable PTSD status at 6 months, as determined by multivariable logistic regression.

Study contacts

Contact information is provided by the study sponsor or research team.

yang li, Master's Student

CONTACT

[email protected]

+86 18089193316

Sponsors and collaborators

Lead sponsor

The First Affiliated Hospital of Air Force Medicial University

Other

Registry information

Important dates

Study start: 2026
Primary completion: 2026
Study completion: 2026
First posted: Apr 15, 2026
Registry last updated: Apr 15, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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