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Completed

NCT Number: NCT04266691

Analysis of Driver Gene Mutation in Early Stage Non-small Cell Lung Cancer

Analysis of driver gene variation in early stage non-small cell lung cancer

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Key information

Conditions

Non-small Cell Lung Cancer Bronchial Neoplasms Carcinoma, Bronchogenic Carcinoma, Non-Small-Cell Lung Lung Diseases Lung Neoplasms Neoplasms Neoplasms by Site Respiratory Tract Diseases Respiratory Tract Neoplasms Thoracic Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

Fluorescence quantitative polymerase chain reaction (PCR) was used to detect the variation of driver gene in regional lymph nodes of early stage non-small cell lung cancer (NSCLC), and to analyze the relationship between the variation and disease recurrence and survival prognosis. evaluate the effect of the variation of driving gene in lymph nodes of early stage NSCLC on prognosis, identify the high-risk factors that promote the recurrence and metastasis of early stage tumor. so as to improve the diagnosis and treatment path of lung cancer, provide important pathological basis for the clinical diagnosis and treatment of early stage non-small cell lung cancer, enable patients to receive more accurate treatment, and improve their survival prognosis.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Female or male, 18 years of age or older
  • Histologically or cytologically proven diagnosis of early stage NSCLC
  • The lesion was completely resected by radical surgery
  • Able to get tumor tissue sample
  • Complete information of clinicopathological , survival, recurrence and metastasis can be obtained through follow-up

Exclusion criteria

  • Combine with other tumor type
  • The investigator judges the situation that may affect the clinical search process and results

Treatment and study plan

nonIntervention

Other

nonIntervention

Primary outcomes

  1. Driver gene mutation frequency of early stage NSCLC

    Time frame: 2019

    Observe the driver gene mutation frequency in regional lymph nodes of early stage non-small cell lung cancer

  2. Correlation of Clinicopathological characteristics and driver gene mutation in regional lymph nodes of early stage NSCLC

    Time frame: 2019

    Analyze the correlation between driver gene mutation and clinicopathological features in regional lymph nodes of early stage NSCLC

  3. Correlation between driver gene mutation and survival prognosis in regional lymph nodes of early stage NSCLC

    Time frame: 2019

    Observe the correlation between driver gene mutation and survival prognosis in regional lymph nodes of early stage NSCLC

Sponsors and collaborators

Lead sponsor

Zhejiang Cancer Hospital

Other

Registry information

Official study title

Molecular Metastasis in Lymph Nodes is Associated With Survival of Patients With Stage I NSCLC

Important dates

Study start
2009
Primary completion
2015
Study completion
2019
First posted
Feb 12, 2020
Registry last updated
Feb 12, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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