Analysis of CMTM6 Expression in Patients With Acute Myeloid Leukemia

In this study, we aim to investigate the expression of CKLF like MARVEL transmembrane domain containing 6 (CMTM6) in leukemia cells of patients with acute myeloid leukemia (AML). We will use peripheral blood samples and assess CMTM6 expression by flow cytometry and Western Blot.

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Key information

Conditions

Acute Myeloid Leukemia, Adult Hematologic Diseases Hemic and Lymphatic Diseases Leukemia Leukemia, Myeloid Leukemia, Myeloid, Acute Neoplasms Neoplasms by Histologic Type

Age range

18 year–99 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Medical Center- University of Freiburg

Freiburg im Breisgau, CA, 79106, Germany

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

age ≥ 18 years
primary diagnosis of acute myeloid leukemia
diagnosis results available
written informed consent
ability to understand the nature of the study and the study related procedures and to comply with them

Exclusion criteria

age < 18 years
lack of informed consent

Treatment and study plan

Primary outcomes

CMTM6 expression (FC)

Time frame: At primary diagnosis

CMTM6 expression on blasts/monocytes will be measured by flow cytometry
T cell activation (FC)

Time frame: At primary diagnosis

T cell activation and cytokine production will be measured by flow cytometry

Secondary outcomes

CMTM6 expression (WB)

Time frame: At primary diagnosis

CMTM6 expression on blasts/monocytes will be measured by Western blot

Sponsors and collaborators

Lead sponsor

University of Freiburg

Other

Registry information

Important dates

Study start: 2020
Primary completion: 2024
Study completion: 2024
First posted: Aug 14, 2023
Registry last updated: May 8, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed