Skip to main content
OpenTrials
Completed

NCT Number: NCT01454635

Analisis of Facors Involved in Antidepressant Treatment Response of Major Depressive Disorder

The purpose of this study is to predict and visualize sertraline treatment response in major depressive disorder with clinical symptoms, demographic and stress state, personality, eight genetic polymorphisms at baseline.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Major Depressive Disorder Behavior Behavioral Symptoms Depression Depressive Disorder Depressive Disorder, Major Mental Disorders Mood Disorders

Age range

20 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Showa University Northern Yokohama Hospital

Yokohama, Kanagawa, 224-8503, Japan

About this study

While only about 50% of patients respond to first treatment in major depressive disorder, 30-40% did not remit after continuous 1 year treatment. However, patients must remain on their prescribed medications for at least 4 weeks without knowing whether the particular antidepressant will be effective. Studies have suggested a number of predictors of treatment response, but varying degrees of success and nearly all with poor prognostic sensitivity and specificity. The investigators investigated clinical symptoms, demographic and stress state, personality and genetic polymorphisms in patients of major depressive disorder treated with sertraline and performed multivariate analysis to extract the predicting factors. Moreover, the investigators tried to visualize weight of variables and pathway one another.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • clinical diagnosis of Major Depressive Disorder
  • Must be able to swallow tablets

Exclusion criteria

  • pregnant
  • breastfeeding

Treatment and study plan

Sertraline

Drug

dosage,frequency and duration

Other names: J Zoloft®

Primary outcomes

  1. Hamilton Rating Scale for Depression

    Time frame: 8 weeks

Sponsors and collaborators

Lead sponsor

Showa University

Other

Registry information

Official study title

Treatment Response Study of Sertraline to Treat Japanese Major Depressive Disorder

Acronym: AFADTRMDD

Important dates

Study start
2008
Primary completion
2010
Study completion
2010
First posted
Oct 19, 2011
Registry last updated
Oct 31, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.