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Completed

NCT Number: NCT05125796

Analgesic Use for Pain Relief in Scorpion Sting

In scorpion stings, patients mostly apply with the complaint of pain. Emergency physicians need to relieve this pain quickly.

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Key information

Conditions

Scorpion Stings Bites and Stings Chemically-Induced Disorders Poisoning Wounds and Injuries

Age range

18 year–100 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Adiyaman University Research Hospital

Adıyaman, Central, 02000, Turkey (Türkiye)

About this study

Aim: In this study, the analgesic efficacy of intravenous (IV) paracetamol, IV dexketoprofen trometamol and topical lidocaine will be compared in patients presenting with pain after scorpion sting.

Methods: This study is a double-blind, randomized, placebo-controlled study conducted in a tertiary emergency department. Adult patients who applied to the study with no systemic findings after scorpion sting and especially with pain will be randomly assigned to one of 4 groups: IV paracetamol, IV dexketoprofen trometamol, topical lidocaine or placebo. In order to determine the intensity of pain, Visual Analog Pain Score (VAS) will be measured at the time of admission to the emergency department, at the 30th minute and at the 60th minute. Afterwards, the VAS score changes between the groups will be compared.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged 18 and over
  • Scorpion sting with pain
  • The diagnostic criteria of Grade 1 for Scorpion sting

Exclusion criteria

  • Patients who denied to give informed consent
  • Taking analgesic treatment (ice application or drugs etc.) in the last 6 hours
  • Any symptoms and findings of systemic toxicity of scorpion sting
  • Pregnant women
  • Hemodynamically unstable patients
  • Known allergy to drugs of the study
  • Patients with renal disease
  • The cases that passed more than 6 hours after the bite

Treatment and study plan

Paracetamol

Drug

1000 mg intravenous paracetamol in 100 mL normal saline

Other names: Paracerol (paracetamol)

dexketoprofen trometamol

Drug

50 mg intravenous dexketoprofen Trometamol in 100 mL normal saline

Other names: Revafen(Dexketoprofen Trometamol)

Lidocaine topical

Drug

Application of 5 gr of 5% topical lidocaine

Other names: Anestol pomade(lidocaine)

Placebo

Drug

100 mL intravenous normal saline infusion+ placebo topical pomade application

Other names: Placebo(intravenous normal saline+placebo topical pomade)

Primary outcomes

  1. Change of the intensity of pain

    Time frame: 30 minutes and 60 minutes after the study drug administered

    Pain intense will be measured by 100 mm visual analog scale (Zero; no pain and 100 mm; the worst pain) after 30th and 60th minutes later after the study drug administered

Secondary outcomes

  1. Adverse events

    Time frame: 60 minutes after the study drug administered

    60 minutes after the study drug administered

  2. need to rescue medication

    Time frame: 60 minutes after the study drug administered

    60 minutes after the study drug administered

Sponsors and collaborators

Lead sponsor

Adiyaman University Research Hospital

Other

Registry information

Official study title

Comparison of iv Paracetamol, iv Dexketoprofen and Topical Lidocaine in Scorpion Sting: a Placebo Randomized Controlled Trial

Important dates

Study start
2020
Primary completion
2021
Study completion
2021
First posted
Nov 18, 2021
Registry last updated
Feb 8, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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