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OpenTrials
Completed

NCT Number: NCT02586454

Analgesic Efficacy of Transmuscular Quadratus Lumborum in Patients Undergoing Total Abdominal Hysterectomy

Patients who have undergone laparotomies often require multimodal postoperative pain regimes. In recent years, abdominal wall blocks have been included to become part of this in order to overcome side effects of systemic opioids and complications from epidural analgesia.

Borglum popularised a new approach on abdominal wall blocks by introducing the transmuscular quadratus lumborum (QL) block. Transmuscular QL block is thought to be effective against somatic and visceral pain as local anaesthetic tends to spread from the site of injection to thoracic paravertebral spaces where the sympathetic chain lies.

The objective of this study is to evaluate the analgesic efficacy of transmuscular QL block in patients undergoing total abdominal hysterectomy (TAH) by measuring cumulative opioid consumption, pain score at rest and on movement 24 hours after TAH. Our hypothesis is patients given transmuscular QL block will have lower cumulative opioid consumption.

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Key information

Conditions

Pain Postoperative Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Age range

20 year–65 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Hospital Kuala Lumpur

Kuala Lumpur, 50586, Malaysia

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ASA I or II
  • Patient's weight > 50kg
  • Elective TAH

Exclusion criteria

  • Body mass index (BMI) > 35 kg/m2
  • Any contraindications to peripheral nerve blocks i.e. local skin infection, coagulopathy, allergy to LA
  • Inability to use patient controlled analgesia
  • Patient on antiplatelet, anticoagulant or on regular use of opioids, paracetamol, nonsteroidal anti-inflammatory drugs or tramadol for chronic condition

Treatment and study plan

Transmuscular quadratus lumborum block

Procedure

Morphine

Drug

Ropivacaine

Drug

Primary outcomes

  1. Cumulative morphine consumption

    Time frame: 24 hours after total abdominal hysterectomy

    in mg for 24 hours

  2. Pain score at rest and movement

    Time frame: 24 hours after total abdominal hysterectomy

    using visual analogue scale 1 to 10

Secondary outcomes

  1. Complications related to the transmuscular QL block

    Time frame: 24 hours after total abdominal hysterectomy

    Complications related to transmuscular QL block: Haematoma at site of injection,infection at site of injection Complications related to PCAM:Nausea, vomiting, pruritus, sedation

Sponsors and collaborators

Lead sponsor

Kuala Lumpur General Hospital

Other Gov

Registry information

Official study title

Transmuscular Quadratus Lumborum Block for Postoperative Pain After Total Abdominal Hysterectomy

Important dates

Study start
2015
Primary completion
2017
Study completion
2017
First posted
Oct 26, 2015
Registry last updated
Jun 20, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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