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Completed

NCT Number: NCT06009302

Analgesic Effects of Extraoral Ultrasound Block of Mandibular Nerve for the Extraction of Lower Third Molars

This is a study about the dynamics and effects of different types of blocks (intraoral conduction anesthesia of the alveolar nerve and extraoral US block of the mandibular nerve) for extraction of lower third molars.

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Key information

Conditions

Molar Impacted Teeth Stomatognathic Diseases Tooth Diseases Tooth, Impacted

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Varazdin General Hospital

Varaždin, 42000, Croatia

About this study

Standard method of anesthesia for extraction of horizontally positioned lower thirdmolars is intraoral conduction anesthesia of the inferior alveolar nerve. However, the analgesiceffect of block is short and it is necessary to use analgesics. In this prospective clinical study,analgesic effect of ultrasound (US) -guided extraoral block of mandibular nerve will beinvestigated, in order to prolong pain-free time and reduce the use of analgesics associated withrisks (bleeding, hepatotoxicity).

Characteristics of alveolar nerve block and US block of the mandibular nerve will becompared, such as: pain during application of anesthesia, amount of anesthetic, duration ofanesthesia, need to use analgesics, time to and level of pain when using analgesics, andcomplications

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age 18-64 years
  • horizontally placed lower third molars
  • ASA I or II group

Exclusion criteria

  • allergy to local anesthetics
  • local infection at the site of needle puncture
  • parotitis
  • serious liver disease
  • use of antiarrhythmics group III (eg amiodarone), anticoagulant or antithrombotic drugs
  • lactation
  • people who took an analgesic as a preventive measure before coming to the procedure

Treatment and study plan

US guided block of mandibular nerve

Procedure

Extraoral ultrasound-guided block of the mandibular nerve will be performed in the examined group using an ultrasound device, using ropivacaine (0.75%, 2.5 mL).

Intraoral block of lower alveolar nerve

Procedure

Block of lower alveolar nerve will be applied intraoraly using articaine+adrenaline

Primary outcomes

  1. Time without pain

    Time frame: first 24 postoperative hours

Secondary outcomes

  1. Time of numbness

    Time frame: first 24 postoperative hours

  2. Pain level when anesthesia is applied

    Time frame: first 24 postoperative hours

    0-10 on VAS

  3. Pain level when painkiller is needed

    Time frame: first 24 postoperative hours

    0-10 on VAS

Sponsors and collaborators

Lead sponsor

Varazdin General Hospital

Other

Collaborators

  • Clinical Hospital Centre Zagreb

Registry information

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
Aug 24, 2023
Registry last updated
Apr 3, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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