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Completed

NCT Number: NCT04555291

Analgesic Effect of the QLB-3 for Patients Undergoing a Total Hip Surgery

Total hip arthroplasty (THA) is one of the main elective orthopedic surgery. Recent studies have proven that patients undergoing an elective THA who are part of a fast track surgery program including an opioid free anesthesia (OFA) presented a decrease of mortality and a reduced in-hospital length of stay. Based on the anatomical knowledges, the Quadratus Lumborum Block seems to be an interesting locoregional technique for patients undergoing THA. So far, there is no recommanded locoregional aesthesia in this indication. The investigators hypothezised that QLB would give an efficient analgesia in the 24h following a THA.

Therefor, the study performed a prospective, randomized, double blind trial in the Nice Universitary hospital of Pasteur 2 and in Arnault Tzanck Institute among all patients who underwent THA, comparing a QLB using ropivacaïne 2mg/ml 20ml vs isotonic saline solution 20 ml.The main end-point is the decrease opiod consumption in the 24h following THA.

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Key information

Conditions

Total Hip Arthroplasty

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CHU de nice - Anesthésie Réanimation, Nice, Alpes-Maritimes, France

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All adult patients with unilateral programmed total hip prosthesis surgery are included in the absence of inclusion criteria.
  • Obligation for all patients to be affiliated with social security
  • Patient Informed Consent Signature

Exclusion criteria

  • chronic opiod consumption
  • pregnancy
  • mental disorder that prevents the usage of the numeric analog scale
  • Contra indications of the realization of QLB
  • Local infection
  • Allergic to the local anesthesia
  • Hemostasis disorder
  • Incapacity of giving the consent : individuals under guardianship by court order, or under judicial protection

Treatment and study plan

Ropivacaine injection

Drug

Realization of the quadratum lumborum block type 3, ultrasounds' guided by the injection of 20 ml of ropivacaïne 2 mg/ml

NaCl

Other

Realization of the quadratum lumborum block type 3, ultrasounds' guided by the injection of 20 ml of NACL

Primary outcomes

  1. Opoïd consumption

    Time frame: At 24 Hours

    The main end point of this study is the decrease of opiod consumption in the 24h following THA.

Secondary outcomes

  1. morphine equivalent dose

    Time frame: At 48 Hours

    following surgery at rest and in motion

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Nice

Other

Registry information

Official study title

Analgesic Efficiency of the Type 3 Quadratum Lumborum Block in Patients Undergoing Total Hip Arthroplasty : a Randomized Double Blinded Trial

Acronym: QLB-3

Important dates

Study start
2022
Primary completion
2023
Study completion
2024
First posted
Sep 18, 2020
Registry last updated
Mar 24, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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