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Completed

NCT Number: NCT05350384

An Unusual Association Between Pancreatic Cancer and Purtscher-like Retinopathy

AN UNUSUAL ASSOCIATION BETWEEN PANCREATIC CANCER AND PURTSCHER-LIKE RETINOPATHY

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Key information

Conditions

Purtscher Retinopathy Digestive System Diseases Digestive System Neoplasms Endocrine Gland Neoplasms Endocrine System Diseases Neoplasms Neoplasms by Site Pancreatic Cancer Pancreatic Diseases Pancreatic Neoplasms

Sex eligibility

Male

Study type

Observational

Primary location

Eva Intagliata

Catania, 95123, Italy

About this study

Purtscher's retinopathy may cause sudden loss of vision of varying severity, secondary to head or chest injury. Its pathophysiology is unclear. Purtscher's-like retinopathy has more attenuated clinical and objective features and can be associated with many non-neoplastic pathologies.

Otherwise, an association of this kind of retinopathy with malignancies has been described once in the Literature (multiple myeloma). We present a case report on a unique association between pancreatic cancer and Purtscher-type retinopathy.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

NONE -

Exclusion criteria

NONE

-

Treatment and study plan

methylprednisolone

Drug

1 g. of methylprednisolone in saline solution 250 cc once a day for 5 days, and one eye drops of Diclofenac per eye 3 times a day for 30 days

Primary outcomes

  1. funduscopic examination

    Time frame: at the onset of symptoms

    At the funduscopic examination the back of the eye showed large yellow spots and retinal hemorrhages in the superficial retina. In the early stages, fluorescein angiography showed hypofluorescence in the area of the yellow-white patches while the late stages showed hyperfluorescence

Secondary outcomes

  1. abdominal CT-scan

    Time frame: at the onset of symptoms

    CT scan of the abdomen revealed a large mass in the tail of the pancreas with direct extension to the vessels of splenic hilum and splenic vein thrombosis. A secondary invasion of the gastric wall and left adrenal gland was also demonstrated. Percutaneous needle biopsy was performed and histopathology showed moderate to poorly differentiated mucinous pancreatic adenocarcinoma.

Other outcomes

  1. Unusual association between Purtscher-like retinopathy and a malignant disease (pancreatic cancer)

    Time frame: at the diagnosis

    Ocular history and medical history were irrelevant.

  2. Therapy

    Time frame: after 1 month from diagnosis

    An improvement of the macular edema and of the sight was reported after one-month administrating 1 g. of methylprednisolone in saline solution 250 cc once a day for 5 days, and one eye drops of Diclofenac per eye 3 times a day. The patient was not found fit for surgical treatment of his pancreatic cancer and therefore oncologic palliative medical treatment was performed.

Sponsors and collaborators

Lead sponsor

University of Catania

Other

Registry information

Official study title

An Unusual Association Between Pancreatic Cancer and Purtscher-like Retinopathy: Presentation of a Unique Case

Important dates

Study start
2021
Primary completion
2021
Study completion
2021
First posted
Apr 28, 2022
Registry last updated
Apr 28, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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