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OpenTrials
Completed

NCT Number: NCT01402479

An Open-labeled Trial of Ramipril in Patients With Migraine

Physiology of migraine involving renin-angiotensin systems (RAS) has been implicated. Ramipril is a broadly-used angiotensin-converting enzyme inhibitor. The investigators attempt to test the efficacy of ramipril on the prophylaxis of migraine attacks.

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Key information

Conditions

Migraine With Hypertension Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Headache Disorders Headache Disorders, Primary Hypertension Migraine Disorders Nervous System Diseases Vascular Diseases

Age range

20 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

Seoul National University Hospital

Seoul, 110-744, South Korea

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with chronic migraine are included in this study. Migraineurs should be aged 20 to 70 years old with the ability to read and understand the self-report scales, including the headache diary, used in this study.

Exclusion criteria

  • Medication overuse headache are excluded in this study.
  • Treatment with other ACEI or medication that may affect ARS
  • Treatment with migraine prophylactic medications or anti-hypertensive agents including β adrenergic receptor or calcium channel blockers
  • Past history of hepatic or renal dysfunction; an abnormal electrocardiography; a psychiatric disorder; a history of substance abuse; pregnancy or lactation; use of anti-psychotics, antidepressants, or anti-anxiety drugs.

Treatment and study plan

Ramipril

Drug

ramipril 2.5mg twice a day

Primary outcomes

  1. headache frequency

    Time frame: 12 week

    headache days

Sponsors and collaborators

Lead sponsor

Seoul National University Hospital

Other

Registry information

Important dates

Study start
2004
Primary completion
2005
Study completion
2005
First posted
Jul 26, 2011
Registry last updated
Aug 8, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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