An Observational Study of Local Relapse After High Grade Osteosarcoma

multicenter retrospective and prospective study in patients with high-grade osteosarcoma

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Key information

Conditions

Osteosarcoma Neoplasms Neoplasms by Histologic Type Neoplasms, Bone Tissue Neoplasms, Connective Tissue Neoplasms, Connective and Soft Tissue Sarcoma

Sex eligibility

All sexes

Study type

Observational

Primary location

IRCCS Istituto Ortopedico Rizzoli, Bologna, BO, Italy

About this study

This is a multicenter retrospective and prospective study that will analyze all cases with of diagnosis of local relapse in high-grade osteosarcoma from 01 January 1980 and all new cases referring to each participant site.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients who experienced LR as first event of recurrence after treatment for localized high-grade osteosarcoma of bone, including cases with synchronous lung metastases
Adequate patient compliance to follow-up visits
Written informed consent prior to any study-specific analysis and/or data collection
No age limits

Exclusion criteria

Cases of LR demonstrated after > 3 months after metastatic disease
Impossibility to ensure adequate compliance

Treatment and study plan

Primary outcomes

post local relapse survival

Time frame: 24 months follow up

the aim of the study is to analyse the factors influencing post local relapse survival

Study contacts

Contact information is provided by the study sponsor or research team.

Emanuela Palmerini, MD

CONTACT

[email protected]

051/6366 ext. 668

Sponsors and collaborators

Lead sponsor

Istituto Ortopedico Rizzoli

Other

Registry information

Acronym: OSTEO LR

Important dates

Study start: 2022
Primary completion: 2026
Study completion: 2026
First posted: Aug 30, 2023
Registry last updated: Sep 22, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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