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OpenTrials
Completed

NCT Number: NCT01674907

An Observational Study of Avastin (Bevacizumab) in First Line in Patients With Metastatic Colorectal Cancer (AVANiS)

This observational study will evaluate the use in clinical practice and the efficacy of Avastin (bevacizumab) in patients with metastatic colorectal cancer who have not received prior chemotherapy treatment in the metastatic setting. Patients for whom the treating physician has decided to initiate therapy with Avastin will be followed for 10 months.

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Key information

Conditions

Colorectal Cancer Colonic Diseases Colorectal Neoplasms Digestive System Diseases Digestive System Neoplasms Gastrointestinal Diseases Gastrointestinal Neoplasms Intestinal Diseases Intestinal Neoplasms Neoplasms Neoplasms by Site Rectal Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Cape Town, South Africa

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients, >/= 18 years of age
  • Histologically confirmed metastatic colorectal cancer without prior chemotherapy in the metastatic setting

Exclusion criteria

  • Contraindications for Avastin according to the locally approved package insert (version 7 April 2006)

Treatment and study plan

Primary outcomes

  1. Dosage/schedule of 1st-line Avastin

    Time frame: approximately 3 years

  2. Duration of treatment

    Time frame: approximately 3 years

  3. Chemotherapy regimens used in clinical practice

    Time frame: approximately 3 years

  4. Clinical/demographic patient characteristics at baseline

    Time frame: approximately 3 years

Secondary outcomes

  1. Progression-free survival

    Time frame: approximately 3 years

  2. Relationship between termination of Avastin treatment and time point of progression

    Time frame: approximately 3 years

Sponsors and collaborators

Lead sponsor

Hoffmann-La Roche

Industry

Registry information

Official study title

Non-interventional Study of Avastin in 1st Line Metastatic Colorectal Cancer

Important dates

Study start
2010
Primary completion
2012
Study completion
2012
First posted
Aug 29, 2012
Registry last updated
Nov 2, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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