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OpenTrials
Completed

NCT Number: NCT06148740

An Investigation of the Effects of a Skin Serum Containing Propolis on Skin Health and Appearance

This is a virtual, single-group clinical trial that will last 8 weeks. Participants will use the Manuka Health Pro Vitality Daily Restorative Face Serum with Propolis & Vitamin C twice daily and complete questionnaires at Baseline, Week 2, Week 4, and Week 8. Participants will also undergo skin analysis via the Optic Elite facial skin analysis system at Baseline and Week 8.

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Key information

Conditions

Skin Health

Age range

30 year–42 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Citruslabs

Santa Monica, California, 90404, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Female between 30-42 years of age.
  • Must be in good general health.
  • Must have concerns with overall skin health and appearance, including:

Spots or blemishes Uneven skin tone Dull-looking skin

  • Must be using the same cleanser, toner, and moisturizer for at least one month prior to starting the study.
  • Must be willing to keep using the same cleanser, toner, and moisturizer for the duration of the study.
  • Must not be using oral or topical retinoids.
  • In the last three months, has not introduced any new medications or supplements that target skin health.
  • Must be willing to comply with the protocol.

Exclusion criteria

  • Anyone with an allergy to bees or bee products.
  • Females who are pregnant or breastfeeding.
  • Unwilling to follow the protocol.
  • Unwilling to maintain use of the same cleaner, toner, and moisturizer for the duration of the study.
  • Currently participating in another study.
  • Use of oral or topical retinoids.
  • Individuals with cystic acne or otherwise self-reported very acne-prone skin.
  • Use of a prescription medication relevant to the skin.
  • Anyone undergoing cosmetic procedures during the study, including Botox, laser, or chemical peel treatments.
  • Anyone sensitive or allergic to any ingredients found in the products.
  • Anyone with severe chronic conditions, including oncological conditions, psychiatric disorders or diabetes.

Treatment and study plan

Manuka Health Pro Vitality Daily Restorative Face Serum with Propolis & Vitamin C

Other

Skin serum containing propolis, vitamin C, and manuka honey.

Primary outcomes

  1. Changes in signs of skin health over time assessed via Optic Elite Skin Analysis. [Timeframe: Baseline to Week 8]

    Time frame: 8 weeks

    The Optic Elite skin analysis system clinically measures the surface and subsurface layers of skin using digital imaging technology. Participants will receive a score that can be compared between time points.

Secondary outcomes

  1. Changes in self-perceived skin clarity. [Timeframe: Baseline to Week 8]

    Time frame: 8 weeks

    Measured via study-specific questionnaires using a 5-point Likert scale. A lower score indicates a more favourable response, with 0=Not noticeable and 4=Severe.

  2. Changes in self-perceived skin hydration. [Timeframe: Baseline to Week 8]

    Time frame: 8 weeks

    Measured via study-specific questionnaires using a 5-point Likert scale. A lower score indicates a more favourable response, with 0=Not noticeable and 4=Severe.

  3. Changes in self-perceived skin texture. [Timeframe: Baseline to Week 8]

    Time frame: 8 weeks

    Measured via study-specific questionnaires using a 5-point Likert scale. A lower score indicates a more favourable response, with 0=Not noticeable and 4=Severe.

  4. Changes in self-perceived skin pigmentation. [Timeframe: Baseline to Week 8]

    Time frame: 8 weeks

    Measured via study-specific questionnaires using a 5-point Likert scale. A lower score indicates a more favourable response, with 0=Not noticeable and 4=Severe.

  5. Changes in self-perceived skin irritation. [Timeframe: Baseline to Week 8]

    Time frame: 8 weeks

    Measured via study-specific questionnaires using a 5-point Likert scale. A lower score indicates a more favourable response, with 0=Not noticeable and 4=Severe.

  6. Changes in self-perceived skin brightness.[Timeframe: Baseline to Week 8]

    Time frame: 8 weeks

    Measured via study-specific questionnaires using a 5-point Likert scale. A lower score indicates a more favourable response, with 0=Not noticeable and 4=Severe.

  7. Changes in self-perceived skin tone evenness. [Timeframe: Baseline to Week 8]

    Time frame: 8 weeks

    Measured via study-specific questionnaires using a 5-point Likert scale. A lower score indicates a more favourable response, with 0=Not noticeable and 4=Severe.

Sponsors and collaborators

Lead sponsor

Manuka Health

Industry

Collaborators

  • Citruslabs

Registry information

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Nov 28, 2023
Registry last updated
Nov 20, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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