An Examination of Blinding for Chinese Herbal Oral Liquid and Matched Placebo

A total of 48 subjects will be divided into two parts for manual scoring, which includes not only the proportion of the discrimination to ZFXN, which is the primary outcome in this study, but also the physical (odor, taste) consistency of the two drugs. The primary outcome was the percentage of ZFXN response. The secondary outcomes included artificial sensory score and intelligent sensory attributes of testing drug.

Inclusion criteria

• 1. Age ≥18 years old;
• 2. No visual, olfactory, taste, cognitive impairment;
• 3. Provide written informed consent by patient (or approved surrogate);

Exclusion criteria

• 1. Evaluation personnel involved in the clinical trial about ZFXN;
• 2. Subjects with severe history of heart, liver, kidney, digestive tract, nervous system, respiratory system, mental disorders or metabolic disorders;
• 3. Subject with history of food, drug allergies, or other allergic diseases (asthma, urticaria, eczematous dermatitis, etc.) or is known to be allergic toZFXN;
• 4. Known definite contraindication to the Chinese herbal medicine;
• 5. Women who are known to be pregnant or lactating;
• 6. Subjects not fit to participate in this study judged by responsible treating clinician.