Nationwide Children's Hospital
Columbus, Ohio, 43205, United States
Location contact
Joseph Tobias, MD
PRINCIPAL_INVESTIGATOR
Julie Rice-Weimer, RN
CONTACT
Not Yet Recruiting
NCT Number: NCT07133412
An Evaluation of the Neuromuscular Junction in Neonates Using the TetraGraph
The goal of this study is to use electromyography-based train-of-four monitoring (TetraGraph™ Neuromuscular Transmission Monitor) as a means of evaluating differences in neuromuscular transmission between infants ≤ 3 months of age and adolescent and older patients (≥ 12 years of age).
Not Yet Recruiting
Trial opening soon.
Get NotifiedKey information
Conditions
Age range
28 day–25 year
Sex eligibility
All sexes
Study type
Interventional
Phase
Not applicable
Primary location
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- ASA 1-3 patients
- Aged 28 days - 3 months or ≥ 12 years
- Undergoing a surgical procedure with a volatile-agent based anesthetic that does not require administration of a neuromuscular blocking agent
Exclusion criteria
- Patients with history of a peripheral neurologic or neuropathic disorder
- Patients in whom the upper extremity cannot be used for TOF monitoring
- Patients undergoing a surgical procedure in which neuromuscular blockade is required
- Edematous patients
- Patients receiving total intravenous anesthesia (TIVA)
Treatment and study plan
TetraGraph
DeviceTetraGraph is a unique, EMG-based portable device for quantitative (objective) monitoring of neuromuscular function. It is a precise and easy to use tool for monitoring depth of block, ensuring adequate recovery of muscle function, and aiding the clinician to reduce the incidence of residual block.
Primary outcomes
-
Amplitude
Time frame: First 30 minutes of surgery
Average amplitude of the evoked response of the muscles.
Study contacts
Contact information is provided by the study sponsor or research team.
Catherine Roth, MPH
CONTACT
Julie Rice-Weimer, RN
CONTACT
Sponsors and collaborators
Lead sponsor
Joseph D. Tobias
Other
Registry information
Official study title
An Evaluation of the Neuromuscular Junction in Infants Using Train-of-four Monitoring With the TetraGraph™ Neuromuscular Transmission Monitor
Important dates
- Study start
- 2026
- Primary completion
- 2027
- Study completion
- 2027
- First posted
- Aug 21, 2025
- Registry last updated
- Apr 3, 2026
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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