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OpenTrials
Completed

NCT Number: NCT01681758

An Assessment of Pulse Pressure Variation to Guide Fluid Therapy in Cardiac Surgery Patients

We aim to test the hypothesis that fluid therapy based on pulse pressure variation (PPV) in patients after cardiac surgery who are mechanically ventilated leads to a significant decrease in the amount of fluid given to such patients in the first 24 hours after surgery

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Key information

Conditions

Cardiac Surgery

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

Austin Hospital

Melbourne, Victoria, 3079, Australia

About this study

  • The investigators will study patients after cardiac surgery
  • The investigators will collect data on standard care in pre-intervention population
  • The investigators will collect demographic and clinical data
  • The investigators will collect biochemical data in the first 24 hours after surgery
  • The investigators will collect biochemical, physiological and clinical outcome data
  • The investigators will compare the standard care and intervention period data

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • immediately after ICU admission after cardiac surgery
  • mandatory mechanical ventilation -

Exclusion criteria

  • Pressure support ventilation
  • ECMO
  • Intra-aortic balloon counterpulsation

Treatment and study plan

IV fluid according to PPV

Other

intravenous fluids

fluids according to standard care

Other

Primary outcomes

  1. Mean amount of fluid given in the first 24 hours after surgery

    Time frame: 24 hours

    all intravenous fluid administered

Secondary outcomes

  1. Physiological outcome

    Time frame: 24 hours

    Blood lactate

Other outcomes

  1. Physiological outcome

    Time frame: 24 hours

    cardiac index

Sponsors and collaborators

Lead sponsor

Austin Health

Other Gov

Registry information

Official study title

A Before-and-after Assessment of Pulse Pressure Variation Guided Fluid Therapy in Cardiac Surgery Patients Receiving Mandatory Mechanical Ventilation

Important dates

Study start
2012
Primary completion
2013
Study completion
2013
First posted
Sep 10, 2012
Registry last updated
Jul 11, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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