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OpenTrials
Completed

NCT Number: NCT04750967

Amitriptyline vs GON and SON Blocks in Migraine

Comparison of efficacy and safety of amitriptyline and nerve blocks

Completed

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Key information

Conditions

Migraine Brain Diseases Central Nervous System Diseases Headache Headache Disorders Headache Disorders, Primary Migraine Disorders Nervous System Diseases Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Cem Bölük

Istanbul, Fatih, 34096, Turkey (Türkiye)

About this study

This study aims to compare the efficacy and safety of amitriptyline and nerve blocks (greater occipital nerve and supraorbital nerve)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosed with migraine according to ICHD-3

Exclusion criteria

  • Being over 50 years or under 18 years
  • Malignancy and other systemic diseases

Treatment and study plan

Lidocaine 1% Injectable Solution

Drug

Repeated injections of lidocaine to greater occipital nerve and supraorbital nerve once a week for first four weeks then once a month for five months

Amitriptyline

Drug

Amitriptyline 25 mg daily

Primary outcomes

  1. Number of Participants with 50% Reduction of Headache Frequency

    Time frame: 6 months

    Monthly headache frequency will be followed

Secondary outcomes

  1. Side effects

    Time frame: 6 months

    Major and minor side effects will be followed

Sponsors and collaborators

Lead sponsor

Dr. Lutfi Kirdar Kartal Training and Research Hospital

Other Gov

Registry information

Official study title

Comparison of Amitriptyline and Nerve Blocks (GON and SON) in Patients With Migraine

Important dates

Study start
2021
Primary completion
2022
Study completion
2023
First posted
Feb 11, 2021
Registry last updated
Sep 8, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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