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NCT Number: NCT07547176

Amino Acid Oxidation of Whole-Food Protein: a Dose-Response Crossover Trial in Young Adults

The purpose of this study is to assess the amino acid oxidation dose-response relationship of ingested whole-food protein in healthy adults. In a randomized, crossover design, 20 young, healthy adult males and females aged 18-35 years, will consume a dinner consisting of 0.32, 0.74, and 1.32 g protein･kg BM-1 (corresponding to 1, 2, and 4 minced beef patties, respectively) during 3 separate experimental trials.The main study endpoint is the amino acid oxidation of ingested protein over a 24-h period.

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Key information

Conditions

Protein Metabolism

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Maastricht University Medical Centre+

Maastricht, Limburg, 6200 MD, Netherlands

Location status: Recruiting

Location contact

Julia M Malowany, MSc

CONTACT

[email protected]

+31 43 388 1617

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged between 18-35 years
  • BMI between 18.5-30 kg/m2
  • Healthy, recreationally active (exercise at least once per two weeks and a maximum of four days per week)
  • No physical limitations (i.e., able to perform all activities associated with daily living independently)

Exclusion criteria

  • Smoking
  • Vegan, vegetarian, or does not consume beef protein
  • Diagnosed musculoskeletal disorders
  • Use of any medications known to affect protein metabolism (i.e., corticosteroids, non-steroidal anti-inflammatories, or prescribed acne medications)
  • Chronic use of gastric acid-suppressing medication or anti-coagulants
  • Unstable weight over the last three months
  • Diagnosed GI tract disorders or diseases
  • Blood donation in the past 2 months
  • Females: pregnancy

Treatment and study plan

Food proteins

Dietary Supplement

Dinner meal consisting of minced beef protein.

Primary outcomes

  1. Amino acid oxidation of ingested protein

    Time frame: Over the 24 hour timeframe following protein ingestion

    Amino acid oxidation; compared between interventions to determine the dose-response relationship of amino acid oxidation to ingested whole-food protein.

Secondary outcomes

  1. Plasma amino acid response of ingested protein

    Time frame: Over the 24 hour timeframe following protein ingestion

    Plasma amino acid response; comparison between interventions to determine the plasma amino acid response to different amounts of ingested whole-food protein.

Study contacts

Contact information is provided by the study sponsor or research team.

Jorn Trommelen, PhD

CONTACT

[email protected]

+31 43 388 1617

Julia M Malowany, MSc

CONTACT

[email protected]

+31 43 388 1617

Sponsors and collaborators

Lead sponsor

Maastricht University Medical Center

Other

Registry information

Acronym: BURGER

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Apr 23, 2026
Registry last updated
Apr 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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