American Heart Association- Stroke/Hypoxia Study

All adverse events will be reviewed for safety and study continuation by the medical monitor.

is a tool used by healthcare providers to objectively quantify the impairment caused by a stroke. The NIHSS is composed of 11 items, each of which scores a specific ability between a 0 and 4. For each item, a score of 0 typically indicates normal function in that specific ability, while a higher score is indicative of some level of impairment. The individual scores from each item are summed in order to calculate a patient's total NIHSS score ranging from 0-44.

A change from baseline to follow up 1 (day 6) is reported, calculated from: value at day 6 - value at baseline

Each test element will be graded on a 3-point ordinal scale and summed up to provide a maximum upper limb score of 66. Reliability and validity have been demonstrated. The FMA will be administered while the subject is seated. A score of 0 indicates no upper extremity function or reflexes, a score of 66 indicates complete control of the paretic upper extremity.

The values reported are differences from follow up (Day 6) and baseline calculated as: value at day 6 - value at baseline

This scale allows for characterization of increases in muscle tone, from low or normal tone to complete limb rigidity. Specifically, we will evaluate the elbow flexors, bilaterally. A score of zero indicates no residual muscle spasticity, a score of 4 is a completely rigid limb with no possible movement. Each participant had their stroke affected elbow joint tested.

The values reported are differences from follow up (Day 6) and baseline calculated as: value at day 6 - value at baseline

A dynamometer measures maximum gross grasp (lb.) averaged over three attempts with each hand. The minimum possible value of zero lb. will be assigned when the participant cannot actively flex the fingers or grasp the dynamometer. Completed bilaterally, if possible The values reported are differences from follow up (Day 6) and baseline calculated as: value at day 6 - value at baseline

Hydraulic Handheld Dynamometer): A dynamometer measures maximum gross grasp (lb.) averaged over 3 attempts with each hand. The minimum possible value of zero lb. will be assigned when the participant cannot actively flex the fingers or grasp the dynamometer. The values reported are differences from follow up (Day 6) and baseline calculated as: value at day 6 - value at baseline

monitoring changes in isometric elbow flexion force using a dynamometer. A total of three trials will be taken on each side, with a rest break between trials. The average of the three trials will be recorded. Strength recorded in lbs, with a minimum value of zero. The values reported are differences from follow up (Day 6) and baseline calculated as: value at day 6 - value at baseline

A neuropsychological measure that seeks to evaluate attention and inhibition. Subjects will be asked to read words or name ink colors as quickly as possible within a given time limit. The test supplies the examiner with three separate scores, including an ability to calculate an interference score. This final score allows for interpretation of cognitive flexibility, creativity and cognitive stress. This measure will be utilized to monitor subjects throughout their participation at specific time-points. Audio recording may be taken to ensure accurate recording of responses. The scale is from 1-18, with 10 being at expected level,. A score below 10 is worse performance than expected, and a score above 10 is greater than expected level. The score reported here is the change in score between Day 6 and baseline The values reported are differences from follow up (Day 6) and baseline calculated as: value at day 6 - value at baseline

Quick short tests to assess clinical status performed by physician to ensure no change in neurologic status, The values reported are the count of participants who were found to have no change in neurolgical status from baseline to day 6 by the clinician