Ambulatory Parkinson's Disease Dyskinesia Monitor for Drug Therapy Titration

The objective is to assess a compact, portable, wireless movement disorder system with continuous monitoring capabilities to detect and quantify the severity of levodopa-induced dyskinesia in Parkinson's disease.

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Key information

Conditions

Parkinson's Disease Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Movement Disorders Nervous System Diseases Neurodegenerative Diseases Parkinson Disease Parkinsonian Disorders Synucleinopathies

Age range

21 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Johns Hopkins Medical Center, Baltimore, Maryland, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Diagnosis of idiopathic Parkinson's disease
Clinical history of levodopa-induced dyskinesia
21 Years of age or older
Stage 2 - 4 OFF-medication on the Hoehn and Yahr scale

Exclusion criteria

Dementia (determined by a neuropsychological assessment)
Severe tremor unaffected by levodopa

Treatment and study plan

Primary outcomes

Correlation between motion sensor features and clinician-rated dyskinesia severity

Time frame: All data will be collected within a single session not to exceed 3 hours

Motor function (movement speed and magnitude measured with a motion sensor) will be collected for a period of 2 hours after taking normally prescribed dose of levodopa.

Sponsors and collaborators

Lead sponsor

Great Lakes NeuroTechnologies Inc.

Industry

Collaborators

Johns Hopkins University
National Institute on Aging (NIA)
University of Rochester

Registry information

Official study title

Kinesia-D Phase II In-Clinic Continuous Assessment Study

Acronym: Kinesia-D

Important dates

Study start: 2014
Primary completion: 2014
Study completion: 2014
First posted: Apr 29, 2014
Registry last updated: Jan 12, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed