Ambroxol Spray Sore Throat Study

Inclusion criteria

• Sore throat due to acute pharyngitis (not more than 72 hours);
• Score of 6 or greater on an 11-point pain intensity numerical rating scale;
• Willingness to remain at the study centre for one hour following the first dose of study medication and return one to three days later.
• Willing to take nothing by mouth except study medication for three hours following the first intake of study medication. Patients must also not smoke during this time period.

Exclusion criteria

• Known allergy to and/or hypersensitivity to ambroxol, sorbitol, or Acetaminophen;
• Patients with drug dependence and/or alcohol abuse;
• Use of any throat lozenge, throat spray, cough drop, menthol-containing product, or any product with demulcent properties within last 2 hours;
• Use of any analgesic/anti-pyretic within last 4 hours;
• Use of any "cold medication" (e.g. decongestant, antihistamine, expectorant, anti-tussive) within last eight hours;
• Use of an antibiotic for an acute illness within last 24 hours;
• Use of inhaled steroids or beta-agonists on a continuous basis during the last week;
• Use of any investigational therapy (including a marketed drug taken for an investigational indication) within last 30 days
• Any sign of mouth-breathing due to nasal congestion;
• Cough that causes throat discomfort;
• Active pulmonary disease such as bronchopneumonia;
• Pregnant, lactating or breastfeeding women,
• Any medical or psychiatric condition which, in the opinion of the investigator, could increase the risks associated with participation in an investigational study or affect compliance with the protocol.
• Patients who have previously enrolled in this study