Ambrosia: Evaluating the Effects of a Food-As-Medicine Platform on Gut Microbiome Composition and Metabolism

Inclusion criteria

• Adults 18 to 64 years old at the time of enrollment at high risk for colorectal cancer, defined as follows:

• EITHER a personal history of colorectal cancer, advanced adenoma, or 3 or more non-advanced adenomas in a single screening
• OR TWO of the following criteria:

• One or more first-degree relatives with a history of colorectal cancer
• Body mass index above 30 (Persephone will calculate given height and weight
• Have smoked an average of 5 or more cigarettes (1/4 pack) per day for a continuous period of 10 years or more.
• Able to provide stool samples at study start and after approximately 5 months
• Willing and able to undergo virtual Medical Nutrition Therapy based on cohort assignment
• Willing to complete online questionnaires concerning diet and lifestyle, in English
• Competency in spoken and written English
• Can provide written informed consent

Exclusion criteria

• Subjects with known HIV, Hepatitis A, Hepatitis B, Hepatitis C
• Known Familial Adenomatous Polyposis or Lynch Syndrome (aka Hereditary Non-Polyposis Colorectal Cancer or HNPCC) diagnosis
• A history of Crohn's Disease, Inflammatory Bowel Disease, or chronic colitis.
• Active cancer in the past 2 years, or currently undergoing any form of cancer therapy.
• Confirmed case of COVID-19 or influenza within one month prior to enrollment
• Oral or systemic antibiotic or probiotic use, or a known GI infection, within 3 months prior to enrollment
• Engaged in a nutritional or dietary intervention in the past 3 months.
• Women who are pregnant or plan to become pregnant in the next 6 months, or currently nursing.