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NCT Number: NCT01315782

Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis

This is an observational study to understand the changes in alveolar dead space in medical critically ill patients with severe infection (severe sepsis) requiring mechanical ventilation and the possibility to predict multi-organ failure.

The measurement of alveolar dead space used to require sophisticated equipment and time. New ventilators have microprocessors that allow rapid mathematical calculation with minimal intervention.

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Key information

Conditions

Sepsis Infections Inflammation Multi-organ Failure Multiple Organ Failure Pathologic Processes Pathological Conditions, Signs and Symptoms Septic Shock Severe Sepsis Shock Shock, Septic Systemic Inflammatory Response Syndrome

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Memorial Hermann Hospital

Houston, Texas, 77030, United States

Location contact

Rosa M Estrada-Y-Martin, MD MSc

CONTACT

[email protected]

713-500-6830

About this study

The patient will be followed during their ICU stay up to two weeks while on mechanical ventilation.

Patient will be followed daily for the initial 48 hours and then once per week for 2 weeks while mechanically ventilated.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults with severe sepsis or septic shock on mechanical ventilation
  • Enrolled in the initial six hours of ICU admission

Exclusion criteria

  • Patients with withdrawal or hospice order.
  • Patients with terminal, irreversible disease, expect to decease in 48 hours from ICU admission.
  • Patients with COPD.
  • Patients transferred from outside ICU with ongoing sepsis management for more than six hours.

Treatment and study plan

Primary outcomes

  1. Multi-organ failure

    Time frame: daily for 48 hours then weekly for 2 weeks.

    Multi-oran failure will be accessed by daily laboratory data, heart function by echocardiogram if available, urinary output, vitals and use of vasopressors.

Secondary outcomes

  1. Mortality

    Time frame: ICU mortality

    All the patient will be followed up to 28-days to determine survival.

Study contacts

Contact information is provided by the study sponsor or research team.

Rosa M Estrada-Y-Martin, MD MSc

CONTACT

[email protected]

713-500-6830

Sponsors and collaborators

Lead sponsor

The University of Texas Health Science Center, Houston

Other

Registry information

Official study title

Alveolar Dead Space as Predictor of Multi-organ Failure and Mortality in Medical Intensive Care Patients With Sepsis Requiring Mechanical Ventilation

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Mar 15, 2011
Registry last updated
Jun 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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