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Enrolling by Invitation

NCT Number: NCT06678386

Alteration of Sweet Taste Perception After Reduction of Sweet Food and Beverage Consumption.

The goal of this clinical trial is to determine whether reducing sugar intake by 50% for 12 weeks can change sweet taste perception in healthy adults and its consequences. The main questions it aims to answer are:

* Does sweet intensity change after reducing daily sugar intake by 50% for 12 weeks? * How does sweet intensity change after completing dietary modification for 8 weeks? * Does individual daily sugar intake change after completing dietary modification for 8 weeks?

Researchers will compare reducing daily sugar intake by 50% for 12 weeks to an unmodified diet to see if sugar reduction can change sweet intensity.

Participants will:

* Reduce daily sugar intake by 50% or maintain an unmodified diet for 12 weeks. * Visit the clinic three times for anthropometric measurements, sweet perception tests, and to complete questionnaires. * Keep a diet record for a total of 15 days during the research period.

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Key information

Conditions

Health-Related Behavior Behavior Health Behavior

Age range

18 year–59 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Medicine Siriraj Hospital, Mahidol University

Bangkoknoi, Bangkok, 10700, Thailand

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • People with a fasting blood sugar level below 126 mg/dL or an HbA1C below 6.5% in the past 6 months, who are not currently being treated for diabetes.
  • People who score 10 or more points on the sweet food consumption behavior questionnaire.
  • People who are able to communicate in the Thai language.
  • People who are able to chat and use video calls via the Line application.
  • People who agree to modify their diet and beverages according to the recommendations of a dietitian.
  • People who agree to undergo sweet taste testing, complete a food record, and fill out a questionnaire.

Exclusion criteria

  • People with uncontrolled chronic conditions who have had changes in their treatment within the past 3 months.
  • People with a history of severe illness in the past 6 months.
  • People who regularly use medication, excluding contraceptives and vitamins.
  • Pregnant women.
  • People who have experienced a weight change of at least 10% over the past 3 months.

Treatment and study plan

50% sugar reduction

Behavioral

Participants were advised by a dietitian to reduce their daily caloric intake from sugars by 50% for 12 weeks.

Primary outcomes

  1. Sweet intensity change from baseline after 12 weeks of the intervention.

    Time frame: 16 weeks from baseline (12 weeks after the start of the intervention)

    Percentage of participants whose sweet intensity has increased after reducing daily sugar intake by 50% for 12 weeks, compared to those with an unmodified diet.

Secondary outcomes

  1. Sweet intensity change from baseline after completing the intervention for 8 weeks.

    Time frame: 24 weeks from baseline

    Percentage of participants whose sweet intensity increased after completing dietary modification for 8 weeks, compared to those with an unmodified diet.

  2. Changes in sugar consumption behavior from baseline

    Time frame: 24 weeks from baseline

    The average daily caloric intake from sugars after completing dietary modification for 8 weeks, compared to before the dietary change.

Sponsors and collaborators

Lead sponsor

Mahidol University

Other

Registry information

Official study title

Alteration of Sweet Taste Perception After 50% Reduction of Sweet Food and Beverage Consumption for 12 Weeks, Compared With Unmodified Diet.

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Nov 7, 2024
Registry last updated
Nov 7, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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