Skip to main content
OpenTrials
Completed

NCT Number: NCT04799873

Alpha-1-Antitrypsin-Deficiency in COVID-19

The blood concentrations of alpha-1-antitrypsin are monitored during COVID-19. The clinical course of patients that received AAT infusion for clinical indication is monitored.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Covid19 COVID-19 Coronaviridae Infections Coronavirus Infections Infections Lung Diseases Nidovirales Infections Pneumonia Pneumonia, Viral RNA Virus Infections Respiratory Tract Diseases Respiratory Tract Infections Virus Diseases

Age range

18 year–110 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Saarland University

Homburg, Saarland, 66421, Germany

About this study

The blood concentrations of alpha-1-antitrypsin are monitored during COVID-19. The clinical course of patients that received AAT infusion for clinical indication is monitored. Clinical outcomes, blood inflammatory markers, and virus load are monitored.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Infection with SARS-COV2
  • Age over 18 years

Exclusion criteria

  • Unability to consent
  • Invasive ventilation

Treatment and study plan

AAT( Alpha 1 Antitrypsin)

Drug

AAT administration based on clinical indication

Other names: AAT administration based on clinical indication

Primary outcomes

  1. Clinical course

    Time frame: 3 months

    Disease course such as death, need for ICU treatment, ventilatory support or deterioration are monitored

Sponsors and collaborators

Lead sponsor

Universität des Saarlandes

Other

Registry information

Official study title

Individual Treatment of COVID-19 by Application of Alpha-1-antitrypsin

Acronym: CORSAAR-AAT

Important dates

Study start
2020
Primary completion
2020
Study completion
2020
First posted
Mar 16, 2021
Registry last updated
May 25, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.