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Completed

NCT Number: NCT01400048

Aloe Vera in Irritable Bowel Syndrome

The purpose of the present study is to study the effect of aloe vera in the treatment of IBS patients in a randomized, double-blind placebo controlled study.

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Key information

Conditions

Irritable Bowel Syndrome Colonic Diseases Colonic Diseases, Functional Digestive System Diseases Gastrointestinal Diseases Intestinal Diseases

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Mag-tarmlab, Dept of Internal Medicine, Sahlgrenska University Hospital

Gothenburg, 413 45, Sweden

About this study

There is limited knowledge of the IBS pathophysiology, absence of biological markers and therefore few effective treatment options. IBS therefore contributes to difficulties in the management of the patients. Aloe vera has a long association with herbal medicine, from the Ebers Papyrus from 16th century BCE. It is alleged to be effective in treatment of wounds, to improve blood glucose levels in diabetics, and it may reduce symptoms and inflammation in patients with ulcerative colitis. Evidence of the effects of aloe vera in the treatment of IBS, is however limited and contradictory.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • IBS according to the Rome III criteria
  • Adults

Exclusion criteria

  • other GI disorders
  • other medical conditions
  • were pregnancy or breast-feeding
  • food allergy or intolerance to other than lactose
  • ongoing intake of aloe vera products

Treatment and study plan

Aloe vera effervescent tablet (AVH200)

Dietary Supplement

250 mg aloe vera and 60 mg ascorbic acid, Aloe Life®

Placebo Control

Dietary Supplement

60mg Ascorbic acid

Primary outcomes

  1. IBS symptoms

    Time frame: 4 weeks

Sponsors and collaborators

Lead sponsor

Sahlgrenska University Hospital

Other

Collaborators

  • Calmino group AB

Registry information

Official study title

Aloe Vera Versus Placebo for Patients With Irritable Bowel Syndrome

Important dates

Study start
2010
Primary completion
2016
Study completion
2017
First posted
Jul 22, 2011
Registry last updated
Sep 10, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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