Allopurinol in Acute Coronary Syndrome

Inclusion criteria

• the people who understand and would sign the informed consent voluntarily;
• Aged 18 to 80 years old;
• hospitalized patients diagnosed as acute coronary syndrome in the past 1 months;

• hsCRP > 2mg/L;
• allopurinol allergy gene HLA-B5801 was negative.

Exclusion criteria

• history of coronary artery bypass grafting;
• allergy to allopurinol or any excipient;
• administration of allopurinol or other uric-acid-lowering drugs within 7 days before randomization;
• abnormal liver function (ALT >1.5 fold of the upper limit);
• renal dysfunction (creatinine clearance rate <45 ml/min);
• thrombocytopenia (PLT<100g/L);
• gout patients;
• uncontrolled infectious diseases in screening period;
• Thyroid dysfunction, moderate to severe anemia (hemoglobin < 90g/L), systemic lupus erythematosus, malignant hematopathy, leukopenia, asthma, inflammatory bowel disease and other immune diseases were found during the screening period;
• Non-steroidal anti-inflammatory drugs, steroid hormone, immunomodulatory and chemotherapeutic drugs not included in the study protocol should be taken for a long time during the study period;
• the history of surgery or interventional operation within 6 months before the screening period;
• patients with mental disorders such as anxiety or depression;
• pregnant women, lactating women or women of childbearing age who did not use effective contraceptive measures ;
• patients who participated in other clinical trials 3 months before the screening period;
• the researchers judged that patients were not suitable for this clinical trials.