Allometric-Pace Study

Inclusion criteria

• Patients are at age of equal to or more than 60 years old
• Patients have plan to implant dual-chamber pacemaker
• Resting sinus heart rate is equal or less than 60 bpm, or average heart rate detected through 24-hour dynamic electrocardiogram is equal or less than 60 bpm
• Patients have diagnosis of SND. If patients have both sinus node dysfunction and AV block, conduction system pacing shall be available
• Patients have a history of hypertension, two times of blood pressure measurements at office visit are equal to or more than 130 mmHg in systolic blood pressure, diastolic pressure is equal or less than 80 bpm

Exclusion criteria

• Patients have or possible concomitant a diagnosis of heart failure, either reduced EF or preserved EF
• Patients have persistent or chronic atrial fibrillation or clinically significant paroxysmal atrial fibrillation
• Previously diagnosed with a history of organic heart disease: including congenital heart disease, coronary heart disease, old myocardial infarction, dilated cardiomyopathy, hypertrophic cardiomyopathy, cardiac amyloidosis, long QT syndrome, etc.
• Patients have a known secondary cause of hypertension
• Patients have hospitalization of a hypertensive emergency in the previous year
• Patients have a history of renal disease or renal-artery diseases
• Severe hepatic or renal dysfunction
• Active acute infection
• Patients cannot submit a signed informed consent form
• Patients are pregnant or plan to be pregnant during study period
• Patients participate in another study that will confound this study