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Enrolling by Invitation

NCT Number: NCT07604142

Allogenic Bone Block for Oro-Antral Communication Closure for Subsequent Implant Placement

13 patients will be included in this study with a badly destructed upper molar indicated for extraction. Cone beam computerized tomography images revealed the presence of a large bone defect associated with oro-antral communication with the maxillary sinus. after extraction, The prefabricated allogenic scaffold will be seated. then 6 months later, implant will be inserted.

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Key information

Conditions

Tooth Loss Fistula Mouth Diseases Oral Fistula Oroantral Fistula Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Periodontal Diseases Stomatognathic Diseases Tooth Diseases

Age range

20 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Dentistry

Tanta, 3111, Egypt

About this study

13 patients will be included in this study with a badly destructed upper molar indicated for extraction. Cone beam computerized tomography images revealed the presence of a large bone defect associated with oro-antral communication with the maxillary sinus. : Extraction will be performed atraumatically using a piezotome surgical motor with an extraction kit. After removal of tooth, oro-antral communication will be verified .The prefabricated CAD-CAM allogenic bone will be seated and covered with nonporous d-PTFE membrane which was secured with simple interrupted sutures. After 6 months, a new CBCT scan will be performed. A mucoperiosteal flap will be reflected ,and a bone biopsy will be taken using a trephine bur. Under strictly aseptic circumstances, the selected implant will be inserted

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ≥ 20 badly destructed upper molar indicated for extraction CBCT revealed the presence of a large bone defect associated with oro-antral communication with the maxillary sinus

Exclusion criteria

  • any systemic disesse affect healing heavy smoker sinus disease

Treatment and study plan

Extraction will be performed atraumatically using a piezotome surgical motor with an extraction kit

Device

Extraction will be performed atraumatically using a piezotome surgical motor with an extraction kit. After removal of tooth, oro-antral communication will be verified .The prefabricated CAD-CAM Allogenic bone will be seated and covered with nonporous d-PTFE membrane

Primary outcomes

  1. the integration of graft

    Time frame: 6 months

    CBCT

  2. histological analysis of graft

    Time frame: 6 months

    histomorphometric analysis

Sponsors and collaborators

Lead sponsor

Tanta University

Other

Registry information

Official study title

Novel Application of CAD-CAM Designed Allogenic Bone Block in Oro-Antral Communication Closure for Subsequent Implant Placement: Radiographic and Histological Analysis

Acronym: CAD-CAM

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
May 22, 2026
Registry last updated
May 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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