Allogenic Adipose-derived Mesenchymal Stem Cells(AMSCs) for Epilepsy During Deep Brain Stimulation(DBS) Surgery

To investigate the feasibility and safety of local delivery of AMSCs for epilepsy by measuring the incidence of AEs related to the study agent.

To investigate the effects of local delivery of AMSCs for epilepsy as measured by radiographic data on MRI.

Inclusion criteria

• Participants ≥ 18 years of age.
• Participants with Drug Resistance Epilepsy as defined by the ILAE5.
• Participants undergoing bilateral implantation of DBS leads into the anterior nucleus of the thalamus.
• Adequate organ function as assessed by the following laboratory values within 3 weeks prior to admission to the study:
• Serum creatinine and urea < 2 times the upper limit of normal;
• ALT, AST and alkaline phosphatase < 3 times the upper limit of normal, and bilirubin < 2.5 mg/dL;
• Prothrombin time ≤ 1.5 times upper limit of normal;
• INR and PTT ≤ 1.5 times the upper limit of normal;
• Hemoglobin ≥ 9 g/dL;
• Platelets ≥ 100 x 10^9/L;
• Absolute Neutrophil Count (ANC) ≥ 1.5 x 10^9/L.
• Patient or legal guardian is able to fully understand and provide written and verbal consent for the protocol.
• Patient is a candidate for ANT DBS based on the following criteria established by the American Society for Stereotactic and Functional Neurosurgeons:
• Confirmed diagnosis of epilepsy by an epileptologist with focal-onset seizures, with or without generalization;
• Failure to adequately control seizures after two (or more) appropriate and adequately-dosed anti-seizure medications;
• Either partial-onset seizures with a localized onset in a region not amenable to resection or following failed resective surgery or focal-onset seizures with distributed or unclear onset zone.

Exclusion criteria

• Patients who have undergone a prior intracranial procedure for epilepsy.
• Patients with an intracranial tumor.
• Confirmed pregnancy.
• History of cancer not in remission for at least 5 years.
• History of diabetes, chronic renal failure, or other significant underlying medical or ----immunosuppressive conditions.
• History of drug or alcohol abuse.
• Subjects allergic to any component of the investigational product.
• Subjects > 75 years of age.
• Cognitively impaired adults.