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Completed

NCT Number: NCT07609524

Alleviation of Cardiometabolic Risk Factors Through Watermelon Rind

To collect data, written consent was obtained from the hospital and university administration. After receiving signed informed consent, the data was collected from cardiac patients.

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Key information

Age range

35 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Lahore

Lahore, Punjab Province, Pakistan

About this study

The target population was adults between the ages of 35 and 65 years who were receiving outpatient care at a hospital or clinic with a diagnosis of either mild to moderate hypertension, mild to moderate alterations in lipid profile or pre-diabetes. To select potential participants from the study population, subjects with a medical history of diabetes, measuring fasting blood glucose, lipid profile and blood pressure were screened.Following screening, participants were divided evenly into three groups: experimental group (1, 2) and one control group. The participants were advised to take 2 slices of bread in breakfast. Individualized plans were given according to their nutrient requirements. A systematic communication plan was developed in order to follow up with participants on their daily consumption of the suggested watermelon rind-based bread through telephonic conversations. For continuous assistance there was a WhatsApp group set up where members may ask issues and get help. The follow up for patients were conducted every month; baseline and after 6 pre-treatments. Appointments for follow-up exams were done after every 15 days in order to track developments, anthropometric measurements were calculated every follow up and modify the dosage as necessary. The baseline and post study test was compared to test the hypothesis.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • The inclusion criterion was target adults with both gender aged 35-65 years. Adults with a diagnosis of mild to moderate hypertension Mild hypertension (140-159/90-99 mm Hg) Moderate hypertension (160-179/100-109 mm Hg) Adults having mild to moderate alterations in lipid profile Triglycerides: 150 to 499 mg/dL LDL-C levels: Mild Alteration (130 to 159 mg/dL) and Moderate Alteration (160 to 189 mg/dL) Adults with pre-diabetes (hbA1c= 5.6-6.4%)

Exclusion criteria

  • Any person allergic to wheat.
  • Any person any person allergic to watermelon rind.
  • Any adult having pancreatitis and hepatitis.
  • Any adults having serious health conditions like cancer.

Treatment and study plan

Control on Wheat bread

Dietary Supplement

Participants were advised to take Two slices of wheat bread in breakfast for the duration of 02 months.

Experimental G1 on WRB

Dietary Supplement

Participants were advised to take 2 slices of Watermelon rind-based bread in breakfast for the duration of 02 months.

Experimental G2 on WRB

Dietary Supplement

Group 2: Participants were advised to take 2 slices of Watermelon rind-based bread in breakfast for the duration of 02 months.

Primary outcomes

  1. Anthropometric Measurements

    Time frame: 60 days

    for body mass index weight in kg and height in meters squared, were used to calculate changes in body size.

  2. Lipid Profile

    Time frame: 60 days

    Blood lipid profile was obtained using fasting blood samples to determine serum total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides were monitored pre and post intervention.

  3. Blood pressure

    Time frame: 60 days

    Blood pressure was checked using an automated sphygmomanometer. Sitting blood pressure was measured in two ways; systolic blood pressure and diastolic blood pressure after 5 minutes rest. For analysis, the average of the three readings were taken.

Sponsors and collaborators

Lead sponsor

University of Lahore

Other

Registry information

Official study title

Alleviation of Cardiometabolic Risk Factors Through Watermelon (Citrullus Lanatus (Thunb.) Matsum. &Amp; Nakai) Rind-based Bread Among Cardiac Patients

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
May 27, 2026
Registry last updated
May 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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