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Completed

NCT Number: NCT01647425

Alcohol and Tobacco Consumption in Patients With Head and Neck or Lung Cancer

This is an multicenter study for preventive and therapeutic strategies for patients with head and neck cancer

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Key information

Conditions

Head and Neck Cancer Alcohol-Related Disorders Alcoholism Chemically-Induced Disorders Head and Neck Neoplasms Lung Cancer Lung Diseases Lung Neoplasms Mental Disorders Neoplasms Neoplasms by Site Respiratory Tract Diseases Respiratory Tract Neoplasms Substance-Related Disorders Thoracic Neoplasms Tobacco Use Disorder

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Centre Hospitalier Régional et Universitaire - Hopital CALMETTE, Lille, France

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About this study

Continuing the chronic intoxication by either tobacco or alcohol after the initial diagnosis of a first lung or head and neck cancer significantly improves the risk of experiencing a second cancer, and largely affects the long term survival. Addiction intervention programs should be personalized according to the patient's profile, with the aim to develop more sustained intervention and monitoring in patients identified at higher risk of not spontaneously stopping harmful substance use. As of today, the trajectories of smoking and drinking habits and the risk factors for persisting smoking or drinking habits have been insufficiently explored among patients with a first lung or head and neck cancer.

The ALTAK study aims to depict the rate of tobacco smokers 12 months after the initial diagnosis of a first lung or head and neck cancer. The secondary objectives of the study are:

  • to depict the rate of alcohol users 12 months after the initial diagnosis of a H&N cancer
  • to depict the rate of tobacco smokers at cancer diagnosis
  • to depict the rate of alcohol users at cancer diagnosis
  • to determine the social, motivational, psychiatric, tobacco-related, alcohol-related, and cannabis-related features associated with stopping tobacco in the year following the diagnosis of a first TARC.
  • to determine the social, psychiatric, tobacco-related, alcohol-related, and cannabis-related features associated with stopping alcohol drinking in the year following the diagnosis of a first H&N cancer

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • first head and neck or lung cancer
  • first support
  • age ≥ 18
  • patient covered by health insurance
  • signed informed consent

Exclusion criteria

  • prior lung or head and neck cancer
  • History of another cancer <5 years, not evolutive and untreated at baseline (carcinoma of the cervix, or basal cell carcinoma of the skin properly treated are allowed). The presence of a second discovery tumor location at the same time as the lung or head and neck cancer, is not a criteria for non-inclusion
  • mesothelioma and oesophageal cancer
  • unable to undergo trail medical follow up (geographical, social and psychological reasons)
  • pregnant or nursing women
  • patient under guardianship

Treatment and study plan

physician assessment

Behavioral
  • Socio-economic conditions and general features: educational level, professional status...
  • Assessment of current and past use of tobacco: current smoking status reported by the patient; in lifelong non-smokers: previous history of passive smoking reported by the patient; breath carbon monoxide level; in past smokers: age of first cigarette, total reported duration of active smoking, breath carbon monoxide level...
  • in current smokers: age of first tobacco use, total reported duration of active smoking; Fagerström Nicotine Dependence Test...
  • Assessment of the current and past uses of alcohol: previous-year assessment using the CAGE questionnaire and the AUDIT Test; average weekly alcohol consumption over the last 12 months...
  • Assessment of current use of cannabis using the Cannabis Abuse Screening Test
  • Psychiatric assessment using the MINI 5.0

Primary outcomes

  1. tobacco consumption

    Time frame: at 12 months

    reported tobacco smoking

Secondary outcomes

  1. tobacco smoking

    Time frame: at baseline, 3 and 6 months

    frequency tobacco consumption

  2. alcohol drinking

    Time frame: at baseline, 3, 6 and 12 months

    frequency of alcohol consumption

  3. progression free survival

    Time frame: at 12 months

    median time between date of inclusion and date of first progression

  4. overall survival

    Time frame: at 12 months

    median time between date of inclusion and date of death

  5. sociodemographic, cancer-related, tobacco-related, alcohol-related, and psychiatric characteristics

    Time frame: at baseline

Sponsors and collaborators

Lead sponsor

Centre Oscar Lambret

Other

Collaborators

  • Centre Régional de Référence en Cancérologie
  • National Cancer Institute, France

Registry information

Official study title

Prevalence and Risk Factors for Persistent Tobacco or Alcohol Use Over the First Year of a First Lung or Head and Neck Cancer

Acronym: ALTAK

Important dates

Study start
2012
Primary completion
2013
Study completion
2014
First posted
Jul 23, 2012
Registry last updated
Mar 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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