Skip to main content
OpenTrials
Completed

NCT Number: NCT00424580

Airway Responses to Montelukast and Desloratadine.

Montelukast (for asthma) and desloratadine (for allergies) are effective therapy for their current uses. Part of what happens when your allergies trigger your asthma should be prevented by either of these drugs. This project is being conducted to determine if these drugs are effective, either alone or in combination, on controlling asthma that is triggered by allergies.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Asthma Bronchial Diseases Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Lung Diseases Lung Diseases, Obstructive Respiratory Hypersensitivity Respiratory Tract Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Room 346 Ellis Hall

Saskatoon, Saskatchewan, S7N 0W8, Canada

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • baseline FEV1 > or = 65% predicted
  • positive methacholine challenge (i.e. methacholine PC20 < or = 16mg/ml
  • positive allergen challenge

Exclusion criteria

  • negative skin prick test
  • lung condition/disease other than asthma
  • currently use montelukast and/or desloratadine

Treatment and study plan

Montelukast (10mg) and Desloratadine (5mg)

Drug

Primary outcomes

  1. Late asthmatic response (maximum percent decrease in FEV1)

Secondary outcomes

  1. Early asthmatic response (maximum percent decrease in FEV1

  2. Changes in sputum cell/mediator content

  3. Changes in airway hyperresponsiveness (methacholine PC20)

Sponsors and collaborators

Lead sponsor

University of Saskatchewan

Other

Registry information

Important dates

Study start
2007
Primary completion
2007
Study completion
2007
First posted
Jan 19, 2007
Registry last updated
Jan 23, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.