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OpenTrials
Completed

NCT Number: NCT01799148

Air Pollution, Inflammation and Acute Coronary Syndrome

The objectives of this study are: 1) To determine whether patients with acute coronary syndrome, the level of environmental exposure to particulate air pollutants in the week prior to admission, are related to concentrations of inflammatory molecules and oxidative stress. 2) To investigate whether the level of environmental exposure is an independent prognostic factor in terms of overall and cardiovascular mortality, myocardial infarction or unstable angina at 30 days, 6 and 12 months.

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Key information

Conditions

Patients With Acute Coronary Syndrome Acute Coronary Syndrome Cardiovascular Diseases Heart Diseases Inflammation Myocardial Ischemia Pathologic Processes Pathological Conditions, Signs and Symptoms Vascular Diseases

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Hospital Universitario de Canarias

San Cristóbal de La Laguna, Santa Cruz de Tenerife, E-38320, Spain

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with acute coronary syndrome

Exclusion criteria

  • Infectious process and / or local or systemic inflammation in the 15 days before admission.
  • Thyrotoxicosis.
  • Neoplasms - or any other disease that seriously compromise the prognosis of life and / or generate a systemic inflammatory response.

Treatment and study plan

Particulate air pollutants

Other

We will determined the average concentrations of different sizes of particulate matter from 1 day or up to 7 days prior to admission in patients with acute coronary syndrome.

Primary outcomes

  1. Impact of air pollution on inflammation, oxidative stress and 1-year prognosis in patients hospitalized for acute coronary syndrome.

    Time frame: 7 days

    A single center, cohort of consecutive patients admitted with diagnosis of acute coronary syndrome in the cardiology unit of a tertiary hospital, which will quantify the exposure of particulate air pollutants 24 hours a day 7 days earlier prior to admission. Also be determined inflammatory molecules and oxidative stress in admission.

Secondary outcomes

  1. Impact of air pollution on inflammation, oxidative stress and 1-year prognosis in patients hospitalized for acute coronary syndrome.

    Time frame: 1 year

    During the evolution of these patients, after 30 days, 6 and 12 months will recorded major adverse cardiovascular events. It also will quantify the exposure of air pollutant particles in all patients included, at 30 days, 6 and 12 months.

Other outcomes

  1. Impact of air pollution on inflammation, oxidative stress and 1-year prognosis in patients hospitalized for acute coronary syndrome:

    Time frame: 1 year

    During the evolution of these patients, after 30 days, 6 and 12 months will recorded major adverse cardiovascular events. It also will quantify the exposure of air pollutant particles in all patients included, at 30 days, 6 and 12 months.

Sponsors and collaborators

Lead sponsor

Fundación Canaria Rafael Clavijo para la Investigación Biomédica

Other

Registry information

Official study title

Impact of AIR Pollution on Inflammation, Oxidative Stress and 1-year Prognosis in Patients Hospitalized for Acute COronary Syndrome

Acronym: AIRACOS

Important dates

Study start
2011
Primary completion
2014
Study completion
2014
First posted
Feb 26, 2013
Registry last updated
Jan 21, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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