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NCT Number: NCT05076630

Air Pollution and Health of COPD Patients

This panel study aims to evaluate the effects of air pollutants on cardiopulmonary health of patients with chronic obstructive pulmonary disease (COPD) and explore the potential biological mechanisms.

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Key information

Conditions

Chronic Obstructive Pulmonary Disease Chronic Disease Disease Attributes Lung Diseases Lung Diseases, Obstructive Pathologic Processes Pathological Conditions, Signs and Symptoms Pulmonary Disease, Chronic Obstructive Respiratory Tract Diseases

Age range

40 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Peking University

Beijing, China, 100191

About this study

This panel study was conducted in a group of stable patients with COPD in Beijing, China. The health measurements including lung function, blood pressure and airway inflammation were conducted, and morning urine, exhaled breath condensate, saliva and venous blood were collected at the time of enrollment and at 3, 6 and 9 months after enrollment. Individual exposures to fine particulate matter (PM2.5), black carbon (BC), ozone (O3) and nitrogen dioxide (NO2) were performed for 24 hours at each follow-up. And the daily concentrations of air pollutants were collected from the Beijing Air Quality Real-time Publishing Platform and meteorological data were collected from the National Meteorological Information Center. The linear mixed effects model was used to analyze the association between air pollution and cardiopulmonary health in patients with COPD.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • doctor-diagnosed stable COPD patients
  • aged 40 to 80 years
  • lived in Beijing for over one year before being recruited
  • Agree to participate and sign the informed consent form.

Exclusion criteria

  • Patients with a history of acute exacerbation in the last 1 month
  • Patients with other respiratory diseases such as bronchiectasis and asthma.

Treatment and study plan

Air pollutants

Other

Particulate matter and gaseous pollutants

Primary outcomes

  1. Lung function

    Time frame: Nine months

    Lung function test was conducted.

Secondary outcomes

  1. COPD Assessment Test scores

    Time frame: Nine months

    COPD Assessment Test (CAT) scores were used to assess quality of life in COPD patients on a scale of 0 to 40, with higher scores associated with poorer outcomes.

  2. Modified British Medical Research Council (mMRC) Questionnaire score

    Time frame: Nine months

    Modified British Medical Research Council (mMRC) Questionnaire score was used to assess the severity of dyspnea on a scale of 0 to 4, with a higher score indicating a worse outcome.

  3. ST. George's Respiratory Questionnaire scores

    Time frame: Nine months

    ST. George's Respiratory Questionnaire (SGRQ) scores were used to assess quality of life in patients with COPD on a scale of 0 to 100, with higher scores indicating poorer outcomes.

  4. Blood pressure

    Time frame: Nine months

    Systolic and diastolic blood pressure of participants were measured at least three times by a trained technician.

  5. Respiratory inflammation

    Time frame: Nine months

    Fractional exhaled nitric oxide (FeNO) test was conducted.

  6. Airway and systemic oxidative stress levels

    Time frame: Nine months

    Exhaled Breath Condensate (EBC) and urine samples were collected for oxidative stress analysis.

  7. Systemic inflammation

    Time frame: Nine months

    Venous blood was collected for determination of systemic inflammatory biomarkers.

Sponsors and collaborators

Lead sponsor

Peking University

Other

Registry information

Official study title

Effect of Air Pollution on Prognosis of Patients With Chronic Obstructive Pulmonary Disease and Its Underlying Biological Mechanism

Important dates

Study start
2021
Primary completion
2024
Study completion
2024
First posted
Oct 13, 2021
Registry last updated
Jun 3, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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