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NCT Number: NCT07405034

AI Driven EX Versus Conventional in PFPS

This study aims to investigate and compare the effect of AI driven exercises program versus the conventional exercises therapy program on pain, function and dynamic knee valgus angle in treatment of patellofemoral pain syndrome.This study is randomized controlled trial and includes 40 participants .These participants divided into 2 groups (A, B), each group will be assessed with 3 measurments (vas ,dynamic knee valgus, Kujala Anterior Knee Pain Scale) and each group will receive difeerent treatments.

The individuals in group A(study group) will preceive AI driven exercises program while the individual in group B will receive conventional exercises therapy program. Participants in the both groups are prescribed a 6-week comprehensive exercises program (3 sessions per week) day after day and assessment procedure will be performed pre and post treatmeant .

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Key information

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

the out-patient clinic faculty of physical therapy, Cairo University,, Cairo, The Capital, Egypt

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About this study

PURPOSE : This study aims to investigate and compare the effect of AI driven exercises program versus the conventional exercises therapy program on pain, function and dynamic knee valgus angle in treatment of patellofemoral pain syndrome.

BACKGROUND:

Patellofemoral pain syndrome (PFPS) is one of the most common knee problems that disturb function and daily activities (Menek et al .,2025). Symptoms of PFPS can develop either slowly or abruptly, and pain tends to worsen with activities such as squatting, prolonged sitting, stair climbing, jumping, or running (Menek et al .,2025). PFPS affects approximately 25% of physically active individuals (Smith et al .,2018).

Core training significantly improves pain and functional limitations in patients with PFP and improves lower extremity motor performance to some extent (Y. Wang et al., 2024). These results draw more attention to the importance of the core muscle performance for both prevention and rehabilitation of the knee injuries

HYPOTHESES:

A-Primary Hypotheses:

This study will hypothesize that:

  • There will be no significant effect of AI driven exercises program on pain in treatment of patients PFPS .
  • There will be no significant effect of AI driven exercises program on function in treatment of patients PFPS .
  • There will be no significant differences of AI driven exercises program and on dynamic knee valgus in treatment of patients PFPS.
  • There will be no significant differences of conventional exercises therapy on pain in treatment of patients PFPS.
  • There will be no significant differences of conventional exercises therapy on function in treatment of patients PFPS.
  • There will be no significant differences of conventional exercises therapy dynamic knee valgus in treatment of patients PFPS.

RESEARCH QUESTION:

This study will try to answer the following questions:

This study will try to answer:What are the effects of of AI driven exercises program and the conventional exercises therapy program on pain, function and dynamic knee valgus angle in treatment of patellofemoral pain syndrome ?

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Their ages range from 18- 40 years old, including both genders (male & female).
  • Their BMI will be ≤ 29 kg/m2.
  • A traumatic knee pain persisting for at least three months.

Exclusion criteria

  • Any congenital deformity of the lower limb,
  • Any recent injuries and surgeries
  • severe foot deformities such as hallux valgus and claw toe
  • Neuromuscular and neurological disorders.- history of patellofemoral dislocation, subluxation .

Treatment and study plan

conventional exercises therapy program

Other

The individual in group B will receive conventional exercises therapy program. Participants are prescribed a 6-week comprehensive exercises program (3 sessions per week) day after day and assessment procedure will be performed pre and post treatmeant

Ai driven EX

Other

The individuals in group A(study group) will preceive AI driven exercises program . Participants in the both groups are prescribed a 6-week comprehensive exercises program (3 sessions per week) day after day and assessment procedure will be performed pre and post treatmeant

Primary outcomes

  1. Kujala Anterior Knee Pain Scale

    Time frame: up to 6 weeks

    a 13-item scale assessing knee functionality. The total Kujala score ranges from 0 to 100, with higher values indicating better performance. Additionally, The Kujala score is known for its reliability and validity in assessing patients with frozen PFPS

Secondary outcomes

  1. visual analog scale

    Time frame: up to 6 weeks

    Pain intensity is assessed using the visual analog scale. Participants are instructed to indicate their pain level on a line ranging from 0 to 10, with 0 representing no pain and 10 indicating unbearable pain

Study contacts

Contact information is provided by the study sponsor or research team.

Alaa Hamdi Rizk, master degree

CONTACT

[email protected]

+201023429731 ext. +201023429731

DINA SAYED ABD ALLAH, Lecturer of Physical Therapy

CONTACT

[email protected]

+20 12 82742057 ext. +20 12 8274205

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Artificial Intelligence Driven Exercises Versus Conventional Exercises Therapy for Patellofemoral

Acronym: AI- PFPS

Important dates

Study start
2026
Primary completion
2026
Study completion
2027
First posted
Feb 12, 2026
Registry last updated
Feb 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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