Sohag University hospitals
Sohag, Egypt
Location status: Recruiting
Recruiting
NCT Number: NCT07043153
AGR+PNI as Predictors of Systemic Lupus Erythematosus Disease Activity
This study aims to evaluate the clinical utility of combining the albumin to globulin ratio (AGR) and the prognostic nutritional index (PNI) as a predictive model for assessing disease activity in patients with systemic lupus erythematosus (SLE). By correlating these nutritional and inflammatory markers with clinical manifestations and laboratory parameters, we hope to establish a simple, non-invasive, and cost-effective tool to aid in monitoring disease activity in Systemic lupus erythematosus patients.
Recruiting
Interested in participating?
Request InfoKey information
Conditions
Age range
18 year and older
Sex eligibility
All sexes
Study type
Observational
Primary location
Who can participate
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- · Age ≥ 18 years.
- Both sexes.
- Patients diagnosed with SLE who fulfilling the Systemic Lupus International Collaborating Clinics (SLICC) classification criteria and matched controls.
Exclusion criteria
- Co-existing chronic inflammatory or autoimmune diseases.
- Age <18 years
- Malignancy.
- Pregnancy or lactation.
- Chronic liver or renal insufficiency.
- Malignant hematologic diseases.
- Active hepatitis.
- Acute infection within the previous four weeks
Treatment and study plan
Albumin to globulin ratio and prognostic nutritional index model
Diagnostic TestMeasurement of albumin to globulin ratio and prognostic nutritional index in participants to assess disease activity in systemic lupus erythematosus patients
Primary outcomes
-
assess the utility of the albumin-to-globulin ratio (AGR) as reliable, non-invasive biomarker for predicting disease activity in patients with systemic lupus erythematosus (SLE).
Time frame: From 6 month to one year
Study contacts
Contact information is provided by the study sponsor or research team.
Esam M Abualfadl, Professor
CONTACT
Hala A Hamid, Master
CONTACT
Sponsors and collaborators
Lead sponsor
Sohag University
Other
Registry information
Official study title
Using Combination of Albumin to Globulin Ratio and Prognostic Nutritional Index Model for Predicting Disease Activity in Patients With Systemic Lupus Erythematosus
Important dates
- Study start
- 2025
- Primary completion
- 2026
- Study completion
- 2026
- First posted
- Jun 29, 2025
- Registry last updated
- May 13, 2026
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.