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Completed

NCT Number: NCT05727254

Agility Training for Older Adults to Improve Fall Risk Factors

In this randomized controlled trial the effect of 4 months of multi-component (strength, balance, cognition, endurance) exercise training intervention on measures of neuromuscular performance, cognition, and endurance as well as neural adaptations on a central and peripheral level is investigated. 40 subjects are recruited that are generally health and between 60 and 80 years of age. The interventions is based around exercises, where different tasks have to be solved simultaneously rather than serially, as has previously been done.

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Key information

Conditions

Age-Related Loss of Skeletal Muscle Mass Aging Atrophy Cognition Disorders Cognitive Decline Cognitive Dysfunction Mental Disorders Muscular Atrophy Nervous System Diseases Neurocognitive Disorders Neurologic Manifestations Neuromuscular Manifestations Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Sarcopenia Signs and Symptoms

Age range

60 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Departement für Sport, Bewegung und Gesundheit

Basel, Canton of Basel-City, 4052, Switzerland

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • willing to be randomized to either arm
  • ability to travel to the sports facility twice a week
  • understanding the german language

Exclusion criteria

  • smoking, obesity
  • history of cardiovascular, pulmonary or chronic inflammatory disease
  • vision impairments
  • orthopaedic problems preventing them from participating in an exercise program
  • history of osteoporosis or recent low trauma fracture
  • less than two weeks during the intervention period
  • not have taken part in a structured exercise program more than once a week in the past three months

Treatment and study plan

Agility training

Behavioral

Multi-component (strength, balance, cognition) exercise training.

Exercise recommendations

Behavioral

Participants are being given the standard recommendations how much exercise and what type older adults should do.

Exercise diary

Behavioral

Participants are instructed to write down their physical activity and exercises.

Primary outcomes

  1. Isometric knee-extension strength

    Time frame: 16 weeks

    Strength in torque (N*m) of the quadriceps femoris muscle. Measured on an isokinetic device in an isometric condition.

Secondary outcomes

  1. Isometric knee-flexion strength

    Time frame: 16 weeks

    Strength in torque (N*m) of the hamstring muscle group measured on an isokinetic device in an isometric condition.

  2. Cognitive Processing Speed

    Time frame: 16 weeks

    Eriksen flanker task performance measured be reaction speed in milliseconds and accuracy in percentage.

  3. Cognitive Impulsiveness

    Time frame: 16 weeks

    Go / No-Go task performance measured by reaction speed in milliseconds and accuracy in percentage.

  4. Balance Performance

    Time frame: 16 weeks

    Staying as stable as possible during ten seconds in tandem stance eyes open condition. Center of pressure sway path length in mm and average sway speed in m/s is calculated.

  5. Hand Grip Strength

    Time frame: 16 weeks

    Using a handheld dynamometer with an extended arm squeezing as hard as possible. Measured in N.

  6. Counter movement jump power

    Time frame: 16 weeks

    Measured on a force plate participants are instructed to jump as high as possible with their hands akimbo. Peak of the time-power curve in Watts.

  7. Blood Pressure

    Time frame: 16 weeks

    Blood pressure cuff on the right arm at the height of the aorta. Measured in mmHG.

  8. Pulse Wave Velocity

    Time frame: 16 weeks

    Estimated from a mobile blood pressure cuff (mobil-O-graph) on the right arm. Measured in m/s.

  9. Retinal vessel diameter

    Time frame: 16 weeks

    A photo is made from the retinal vessels with a static vessel analyzer (camera)through the eye and the vessel diameters are measured in mikrometers.

  10. Quality of Life Questionnaire

    Time frame: 16 weeks

    26 item questionnaire (WHOQOL-Bref). Every answer is rated on a scale from 1 to 5. Aggregate Score from 0 to 100.

  11. Fall Efficacy

    Time frame: 16 weeks

    16 item qestionnaire (Fall Efficacy Scale). Every answer is rated on a scale from 1 to 4.

  12. Sleep Disturbances

    Time frame: 16 weeks

    7 item questionnaire (Insomnia Severity Index). Every answer is rated on a scale from 1 to 5.

  13. Stress

    Time frame: 16 weeks

    10 item qestionnaire (Perceived Stress Scale). Every answer is rated on a scale from 1 to 5.

  14. Depression

    Time frame: 16 weeks

    15 item questionnaire (Center for Epidemiological Studies Depression Scale). Every answer is rated on a scale from 1 to 4.

Other outcomes

  1. Corticospinal Inhibition

    Time frame: 16 weeks

    Difference between paired and single pulse motor evoked potential by transcranial magnetic stimulation.

  2. Voluntary activation

    Time frame: 16 weeks

    Degree of ability to contract the soleus muscle voluntarily.

Sponsors and collaborators

Lead sponsor

Oliver Faude

Other

Registry information

Official study title

Agility Training for Older Adults: A Randomized Controlled Trial

Acronym: AgilE

Important dates

Study start
2022
Primary completion
2023
Study completion
2023
First posted
Feb 14, 2023
Registry last updated
Apr 3, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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