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Completed

NCT Number: NCT04572139

Age-related Differences in Response to Pituitary Stimulation Tests

The purpose of this study to age-related differences to the response of a combined pituitary stimulation test with TRH, LHRH and ACTH.

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Key information

Conditions

Pituitary Aging Brain Diseases Central Nervous System Diseases Endocrine System Diseases Hypothalamic Diseases Nervous System Diseases Pituitary Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Geriatric Medicine, Aalborg University Hospital

Aalborg, Northen Jutland, 9000, Denmark

About this study

Participants will be recruited in three different age intervals: 18-45 years, 55-80 years and 80+ years. These participants will all undergo the same stimulation test with 0.1 mg LHRH, 0.2 mg TRH, and 0.25 mg ACTH (Synachten). The tests will be perfomed at the same time of day for all particpants (between 08:15 and 08:45) and participants will be fasting for the test. Blood samples will be taken just before and at 10, 20, 30, 45, 60, 90 and 120 minutes following the stimulation test. Serum from blood samples will be stored at -20 degrees until analysis.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Ages between 18-45 or above 55.
  • Healthy Volunteers

Exclusion criteria

  • Medication or conditions affecting pituitary response (such as hormonal birth control, steriod use, thyroid disorders)
  • Pregnancy or birth within the last year
  • inability to give informed consent

Treatment and study plan

Pituitary stimulation test

Diagnostic Test

Pituitary stimulation with 0.1 mg LHRH, 0.2 mg TRH and 0.25 mg ACTH

Primary outcomes

  1. Differences in area under the curve in TSH.

    Time frame: Immediately after procedure.

    Differences will be measured by calculating the area under the curve adjusted for the basal level for the time of the test period.

  2. Differences in area under the curve in Prolactin.

    Time frame: Immediately after procedure.

    Differences will be measured by calculating the area under the curve adjusted for the basal level for the time of the test period.

  3. Differences in area under the curve in LH.

    Time frame: Immediately after procedure.

    Differences will be measured by calculating the area under the curve adjusted for the basal level for the time of the test period.

  4. Differences in area under the curve in FSH.

    Time frame: Immediately after procedure.

    Differences will be measured by calculating the area under the curve adjusted for the basal level for the time of the test period.

  5. Differences in area under the curve in Cortisol.

    Time frame: Immediately after procedure.

    Differences will be measured by calculating the area under the curve adjusted for the basal level for the time of the test period.

Other outcomes

  1. Differences in peak values in TSH

    Time frame: Immediately after procedure.

    Both absolute peak values and peak values relative to basal level will be calculated.

  2. Differences in peak values in Prolactin

    Time frame: Immediately after procedure.

    Both absolute peak values and peak values relative to basal level will be calculated.

  3. Differences in peak values in LH

    Time frame: Immediately after procedure.

    Both absolute peak values and peak values relative to basal level will be calculated.

  4. Differences in peak values in FSH

    Time frame: Immediately after procedure.

    Both absolute peak values and peak values relative to basal level will be calculated.

  5. Differences in peak values in Cortisol

    Time frame: Immediately after procedure.

    Both absolute peak values and peak values relative to basal level will be calculated.

  6. Differences in time to peak for TSH.

    Time frame: Immediately after procedure.

    Delayed responses will be examined by inspecting curves and by comparing area under the curve at the different blood sampling time points during the test.

  7. Differences in time to peak for Prolactin.

    Time frame: Immediately after procedure.

    Delayed responses will be examined by inspecting curves and by comparing area under the curve at the different blood sampling time points during the test.

  8. Differences in time to peak for LH.

    Time frame: Immediately after procedure.

    Delayed responses will be examined by inspecting curves and by comparing area under the curve at the different blood sampling time points during the test.

  9. Differences in time to peak for FSH.

    Time frame: Immediately after procedure.

    Delayed responses will be examined by inspecting curves and by comparing area under the curve at the different blood sampling time points during the test.

  10. Differences in time to peak for Cortisol.

    Time frame: Immediately after procedure.

    Delayed responses will be examined by inspecting curves and by comparing area under the curve at the different blood sampling time points during the test.

Sponsors and collaborators

Lead sponsor

Aalborg University Hospital

Other

Registry information

Official study title

Age-related Differences in the Response to a Combined Pituitary Stimulation Test With TRH, LHRH and ACTH

Important dates

Study start
2020
Primary completion
2022
Study completion
2024
First posted
Oct 1, 2020
Registry last updated
Jul 16, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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