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NCT Number: NCT06643403

Age-related Changes in Retinal Oxygen Extraction in Healthy Subjects

It has been found that several systemic and ocular diseases are associated with impaired retinal oxygen extraction. In the present study, retinal oxygen extraction will be measured in different age groups in order to identify age related changes in otherwise healthy subjects. In addition, the study will explore short-term changes in retinal metabolism induced by breathing pure oxygen. Measurements will be performed with dynamic vessel analyzer and laser speckle flowgraphy to evaluate retinal blood flow and retinal oxygen saturation, in order to calculate retinal oxygen extraction.

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Key information

Conditions

Healthy Participants Retinal Oxygen Extraction

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Clinical Pharmacology, Medical University of Vienna, Austria

Vienna, State of Vienna, 1090, Austria

Location status: Recruiting

Location contact

Doreen Schmidl-Schordje, MD

CONTACT

[email protected]

+43 1 40400 ext. 29810

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Men and women aged between 18 and 80 years
  • Signed informed consent
  • Normal ophthalmic findings, unless the investigator considers an abnormality to be clinically irrelevant for the purpose of the study
  • Normal findings in the medical history, unless the investigator considers an abnormality to be clinically irrelevant for the purpose of the study
  • Nonsmokers

Exclusion criteria

  • Abuse of alcoholic beverages or drugs
  • Participation in a clinical trial in the 3 weeks preceding the study
  • Symptoms of a clinically relevant illness in the 3 weeks before the first study day
  • Blood donation during the previous 3 weeks
  • Pregnant or breast-feeding women

Treatment and study plan

Oxygen 100% Gas for Inhalation

Drug

SAUERSTOFF medizinisch, Messer GmbH, Industriestrasse 5, 2352 Gumpoldskirchen, Austria

Dose:

min. 95.5%, breathing for max. 45 minutes

Primary outcomes

  1. Retinal oxygen extraction in different age groups

    Time frame: 15 minutes

Study contacts

Contact information is provided by the study sponsor or research team.

Doreen Schmidl-Schordje, MD

CONTACT

[email protected]

+43 1 40400 ext. 29810

Sponsors and collaborators

Lead sponsor

Medical University of Vienna

Other

Registry information

Important dates

Study start
2024
Primary completion
2025
Study completion
2026
First posted
Oct 16, 2024
Registry last updated
Nov 21, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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