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Completed

NCT Number: NCT04545372

Aerobic Exercises for Multiple Sclerosis

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) .It is the most common neurological disorders affecting young adults.Multiple sclerosis is an autoimmune disease that results in progressive neural degeneration. Cytokines play an important role in the pathogenesis and treatment of MS.

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Key information

Conditions

Multiple Sclerosis, Primary Progressive Autoimmune Diseases Autoimmune Diseases of the Nervous System Chronic Disease Demyelinating Autoimmune Diseases, CNS Demyelinating Diseases Disease Attributes Immune System Diseases Multiple Sclerosis Multiple Sclerosis, Chronic Progressive Nervous System Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

25 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

South Valley University, Faculty of Physical Therapy

Qina, 83523, Egypt

About this study

This research aims to evaluate the effect of aerobic exercises on the immune system anti-inflammatory (IL-10) and pro inflammatory (IL-17) cytokines and its consequences on the functional status in the Multiple Sclerosis patients.

Aerobic exercises are a term to describe planned, structured and repetitive physical activity undertaken over a prolonged period to maintain or improve physical fitness and functional capacity .

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

age ranged from 25 to 45 years. All the patients were remitting relapsing MS according to (revised McDonald criteria.

Duration of MS disease was one to two years before starting of the study. Last attack occurred three months ago. All patients were able to ambulate

Exclusion criteria

Patients with other neurological deficits , patient with significant orthopedic abnormalities for both lower limbs, patient with contracture , patient with deformities, pregnant females

Treatment and study plan

Aerobic Exercise

Other

Primary outcomes

  1. blood analysis

    Time frame: serum anti inflammatory cytokine IL-10, will be assessed at 0 day

    serum anti inflammatory cytokine IL-10,

  2. blood analysis

    Time frame: serum anti inflammatory cytokine IL-10, wil lbe assessed at 90 day

    serum anti inflammatory cytokine IL-10,

  3. blood analysis

    Time frame: pro inflammatory cytokine IL-17 will be assessed at 0 day

    pro inflammatory cytokine IL-17

  4. blood analysis

    Time frame: pro inflammatory cytokine IL-17 will be assessed at 90 day

    pro inflammatory cytokine IL-17

Sponsors and collaborators

Lead sponsor

South Valley University

Other

Registry information

Official study title

Effect of Aerobic Exercises on Immune System in Patients With Multiple Sclerosis

Important dates

Study start
2015
Primary completion
2018
Study completion
2020
First posted
Sep 11, 2020
Registry last updated
Sep 11, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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