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NCT Number: NCT07076888

Aerobic Exercises and Hemodialysis Patients

Patients undergoing hemodialysis (HD) frequently exhibit elevated serum uric acid (SUA) levels, which are associated with cardiovascular risks, joint issues, and diminished quality of life (QoL). Aerobic exercise has been shown to improve cardiovascular health and reduce SUA levels in various populations, suggesting potential benefits for HD patients.

Objective: This study aimed to investigate the impact of aerobic exercise on serum uric acid (SUA) levels, functional capacity, and quality of life (QoL) in patients undergoing hemodialysis (HD).

Methods: This randomized controlled trial will recruit 32 participants, aged 40-60, undergoing HD. The intervention group (Group A) will participate in a structured 6-week aerobic exercise program, while the control group (Group B) will receive only conventional physical therapy. Pre- and post-intervention assessments included SUA levels, the Six-Minute Walk Test (6MWT), and the Kidney Disease Quality of Life Short Form (KDQOL-SF™)

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Key information

Conditions

Hemodialysis

Age range

40 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Physical Therapy faculty, Cairo University

Cairo, Egypt

Location status: Recruiting

Location contact

Doaa Assistant professor of physical therapy, Assistant professor

CONTACT

[email protected]

00201005591580

About this study

32 Subjects of both genders will participate in this study at El-khazendara Hospitals with age ranged between (40-60) years old. They will receive a comprehensive verbal and written explanation of the study, including its objectives, procedures, and potential benefits.

participants will randomly assigned into two equal groups using a sealed-envelope randomization method to ensure unbiased allocation.

  • Group A (study Group): 16 HD patients receiving a conventional physical therapy program (breathing, stretching, and lower limb circulatory exercises) plus the aerobic exercise program.
  • Group B (Control Group): 16 HD patients receiving only the conventional physical therapy program.

6-weeks of aerobic exercise program (3 sessions per week, 20-45 minutes each session)

Outcome measures include:

  • Serum Uric Acid: Measured using an automated biochemistry analyzer, with results reported in mg/dL.
  • Functional Capacity: Assessed using the Six-Minute Walk Test (6MWT), a validated tool used to evaluate exercise tolerance and endurance in clinical populations.
  • Quality of Life:Measured using the Kidney Disease Quality of Life Short Form (KDQOL-SF™) Arabic Version, which assesses various domains related to both physical and mental health.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Hemodialysis patients aged 40-60years
  • Patients are medically stable and able to participate in physical activity.
  • Participants are able to understand the commands.
  • Participants must be stable on hemodialysis for at least 3 months.

Exclusion criteria

  • Patients with significant cardiovascular or respiratory diseases, or other conditions that could impair their ability to exercise.
  • Severe cognitive impairment or psychiatric conditions that could interfere with study participation.
  • patients with acute medical conditions.

Treatment and study plan

aerobic exercises

Other
  • Timing of Exercise:

Aerobic exercises were performed on non-dialysis days. This scheduling avoids post-dialysis fatigue and hypotensive effects, optimizing patient safety and performance.

  • Frequency:

Patients was engaged in aerobic exercise 3 times per week on non-consecutive days, to allow sufficient recovery time between sessions.

  • Duration of Each Session:
  • Total Duration: Each exercise session was last between 20 to 45 minutes.
  • Warm-Up: 5-10 minutes of low-intensity activity (e.g., slow walking).
  • Main Exercise: 15-30 minutes of moderate-intensity aerobic exercise.
  • Cool-Down:*5-10 minutes of gradual reduction in intensity.
  • Exercise Modality:
  • Options: Patients may choose between treadmill walking or using a stationary bike, depending on their preference, physical condition.
  • Variety: To maintain engagement and reduce monotony, patients can alternate between treadmill and bike exercises.
  • Intensity:

Use moderate-intensity exercise, aiming for 60-70% of the p

Conventional Program

Other
  • Breathing Exercises
  • Diaphragmatic Breathing: Instruct patients to place one hand on their chest and the other on their abdomen. They should inhale deeply through their nose, allowing the abdomen to rise, and then exhale slowly through their mouth. This breathing technique has been shown to reduce stress, improve respiratory efficiency, and enhance relaxation . For optimal benefits, patients should practice this for 5-10 minutes, 2-3 times a day.

Stretching Exercises Hamstring Stretch: Instruct patients to sit with one leg extended straight out in front of them and the other leg bent. They should reach towards the toes of the extended leg while keeping their back straight. Hold the stretch for 20-30 seconds and repeat the stretch 2-3 times per leg.

Lower Limb Circulatory Exercises Ankle Pumps: While lying down or seated, instruct patients to alternately point and flex their feet to stimulate circulation and improve lower leg mobility. Perform 20-30 pumps per foot, 2-3 times a day

Primary outcomes

  1. Serum Uric Acid

    Time frame: from enrollment to the end of 6 weeks of treatment

Secondary outcomes

  1. Change in Functional ability of the patient

    Time frame: from enrollment to the end of 6 weeks of treatment

    Assessed by using the Six-Minute Walk Test (6MWT), a validated tool used to evaluate exercise tolerance and endurance in clinical populations.

  2. Change in Quality of life

    Time frame: from enrollment to the end of 6 weeks of treatment

    Kidney Disease Quality of Life Short Form (KDQOL-SF™): The KDQOL-SF™ is a key tool used to assess the quality of life in patients with chronic kidney disease, particularly those undergoing hemodialysis. This version of the questionnaire measures multiple domains, including physical functioning, emotional well-being, and social roles, with a focus on issues specific to kidney disease such as symptoms, work status, and patient satisfaction. The scores are transformed into a scale from 0 to 100, with higher scores indicating a better quality of life

Study contacts

Contact information is provided by the study sponsor or research team.

Doaa Rafat Assistant professor of physical therapy - Cairo university

CONTACT

[email protected]

201005591580

Mahetab Gamal Ali

CONTACT

[email protected]

201009502621

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Impact of Aerobic Exercises on Serum Uric Acid Levels in Hemodialysis Patients

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Jul 22, 2025
Registry last updated
Nov 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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