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Completed

NCT Number: NCT02371733

Aerobic Exercise Training in Pulmonary Arterial Hypertension

Decreased exercise capacity, peripheral muscle strength and quality of life and increased dyspnea and fatigue perception is prevalent in patients with pulmonary arterial hypertension. It was demonstrated exercise training has beneficial effects in patients with pulmonary arterial hypertension. However, no study investigated the effects of upper extremity aerobic exercise training, therefore effects of upper extremity aerobic exercise training on outcomes in patients with pulmonary arterial hypertension.

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Key information

Conditions

Pulmonary Arterial Hypertension Hypertension, Pulmonary Lung Diseases Respiratory Tract Diseases

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Gazi University

Ankara, 06500, Turkey (Türkiye)

About this study

Patients were diagnosed with pulmonary arterial hypertension according to the Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of f the European Society of Cardiology (ESC) and European Respiratory Society (ERS). Primary outcome measurement was exercise capacity, secondary outcomes were respiratory and peripheral muscle strength, physical activity, quality of life, fatigue, dyspnea and depression.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Clinically stable
  • Under standard medication
  • Group 1 pulmonary arterial hypertension patients
  • Having no exacerbation or infection

Exclusion criteria

  • Cognitive disorders
  • Orthopedic and neurological problems
  • Pneumonia or acute infection
  • Stage 4 heart failure
  • Having no comorbidity to avoid performing evaluation and training

Treatment and study plan

Upper extremity aerobic exercise training

Other

Training group will receive upper extremity aerobic exercise training using arm ergometer at 50-80% of maximal heart rate and breathing exercises.

Training will exercise with arm ergometer 3days/week, for 6 weeks with the assistance of a physiotherapist. Training workload will be undercontrol both using target heart rate and Modified Borg dyspnea scale. Training group will also perform breathing exercises 120 times/day, 7 days/week, for 6 weeks.

Alternative upper extremity exercises

Other

Control group will receive alternative upper extremity exercises and breathing exercises. Control group will perform alternative upper extremity exercises 3days/week, for 6 weeks and also breathing exercises 120 times/day, 7 days/week, for 6 weeks.

Control group will be followed-up by telephone once a week.

Primary outcomes

  1. Functional exercise capacity (Oxygen consumption measurement during test)

    Time frame: 6 weeks

    Six minute walk test (6MWT)

Secondary outcomes

  1. Maximum inspiratory and expiratory muscle strength (MIP, MEP)

    Time frame: 6 weeks

    Mouth pressure device

  2. Peripheral muscle strength

    Time frame: 6 weeks

    Hand held dynamometer

  3. Pulmonary functions

    Time frame: 6 week

    Spirometry

  4. Physical activity

    Time frame: 6 weeks

    Activity monitor

  5. Dyspnea

    Time frame: 6 weeks

    Modified Borg and Modified Medical Research Council (MMRC) dyspnea scales

  6. Fatigue

    Time frame: 6 weeks

    Fatigue Severity Scale (FSS)

  7. Generic quality of life

    Time frame: 6 weeks

    Short Form (SF-36) Health Survey

  8. Depression

    Time frame: 6 weeks

    Montgomery Asberg Depression Rating Scale (MADRS) (Turkish versions of all scales)

Sponsors and collaborators

Lead sponsor

Gazi University

Other

Registry information

Official study title

Effects of Upper Extremity Aerobic Exercise Training on Functional Exercise Capacity in Patients With Pulmonary Arterial Hypertension

Important dates

Study start
2015
Primary completion
2018
Study completion
2018
First posted
Feb 26, 2015
Registry last updated
Feb 15, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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