Aerobic Exercise on Ventilatory Efficiency in CAD Patients

The purpose of the present study was to test the hypothesis that patients with coronary artery disease with lower aerobic fitness exhibit greater responsiveness on improving ventilatory efficiency after aerobic exercise training.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Coronary Artery Disease Arterial Occlusive Diseases Arteriosclerosis Behavior Cardiovascular Diseases Complication, Cardio-respiratory Coronary Disease Exercise Addiction Heart Diseases Motor Activity Myocardial Ischemia Vascular Diseases

Age range

48 year–77 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

About this study

Measurements of ventilatory efficiency during cardiorespiratory exercise testing typically expressed as the minute ventilation/ carbon dioxide production ratio have been validated to be useful in assessing the presence and severity of both heart and lung diseases. In this context, previous studies have showed ventilatory inefficiency in patients with coronary artery disease suggests abnormalities in the distribution of ventilation and perfusion in the lungs. In addition, a growing body of studies has demonstrated that lower ventilatory efficiency during exercise is considered an important predictor of risk mortality, hospitalization, and other outcomes than peak VO2.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

was stable coronary artery disease diagnosed by coronary angiography

Exclusion criteria

unstable angina pectoris,
complex ventricular arrhythmias,
pulmonary congestion and
orthopaedic or neurological limitations to exercise

Treatment and study plan

Aerobic exercise training

Other

The exercise training program was comprised of three 60-minute exercise sessions per week over a 3-month period. Each exercise session consisted of a 5 minute warm up, 30-50 minutes of aerobic exercise performed on a treadmill and 5 minutes of cool-down exercises. Aerobic exercise intensity was set at the corresponding heart rate between the VAT and RCP. All patients were able to achieve the set aerobic training intensity.

Primary outcomes

Ventilatory efficiency in patients with coronary artery disease

Time frame: up to 3 months of the interventions

Measurements of ventilatory efficiency during cardiopulmonary exercise testing typically expressed as the minute ventilation/ carbon dioxide production ratio have been validated to be useful in assessing the presence and severity of both heart and lung diseases. In this context, previous studies have showed ventilatory inefficiency in patients with coronary artery disease suggests abnormalities in the distribution of ventilation and perfusion in the lungs.

Sponsors and collaborators

Lead sponsor

Hospital TotalCor

Other

Registry information

Official study title

Effect of Aerobic Exercise Training on Ventilatory Efficiency in Patients With Coronary Artery Disease

Important dates

Study start: 2011
Primary completion: 2012
Study completion: 2013
First posted: Apr 8, 2014
Registry last updated: Apr 8, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed