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Completed

NCT Number: NCT06956963

Aerobic Exercise: A Potential Rescue From the Negative Ramifications of Poor Sleep

The goal of this interventional study is to differentiate the effects of an acute partial sleep deprivation intervention on markers of cardiovascular health, cardio-autonomic function, physical and cognitive performance, as well as overall wellbeing in active vs sedentary individuals. The main aims of the project are:

* To differentiate the effects of partial sleep deprivation on central hemodynamics (i.e., central blood pressure and arterial stiffness) in active vs sedentary individuals. * To differentiate the effects of partial sleep deprivation on physical (i.e., handgrip strength and reactive strength index) and cognitive performance (i.e., reaction time and impulse control) in active vs sedentary individuals. * To differentiate the effects of partial sleep deprivation on overall wellbeing (i.e., cardio-autonomic function, inflammation levels, and psychological mood states) in active vs sedentary individuals.

Participants will be divided into two groups based on aerobic activity level - active or sedentary - and assessed for markers of cardiovascular health, cardio-autonomic function, physical and cognitive performance, as well as overall wellbeing before and after three days of normal sleep and three days of partially deprived sleep (i.e., 30% reduction in total time in bed).

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Key information

Conditions

Cardiovascular Health Sleep

Age range

18 year–39 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Institute of Sports Sciences and Medicine

Tallahassee, Florida, 32301, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Chronically active (≥150 minutes of moderate- and/or ≥75 minutes of vigorous-intensity aerobic exercise per week for the last 3 months) OR
  • Sedentary (≤60 minutes of aerobic exercise per week for the last 3 months)

Exclusion criteria

  • Chronic, uncontrolled disease (cardiovascular, metabolic)
  • Poor sleep (regularly achieving <7 hours of sleep per night)
  • Musculoskeletal injury in the last 6 months
  • Obese (grade II or higher)
  • Pregnant

Treatment and study plan

Partial Sleep Deprivation

Other

30% reduction in habitual time in bed

Other names: Reduced Sleep

Primary outcomes

  1. Arterial Stiffness

    Time frame: Following 3-days of Acute Sleep Deprivation (i.e., 30% reduction in total time in bed) as well as following 3-days of Normal Sleep (i.e., 100% habitual time in bed); performed in a randomized order

    Carotid-femoral pulse wave velocity measured via applanation tonometry

Sponsors and collaborators

Lead sponsor

Florida State University

Other

Registry information

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
May 4, 2025
Registry last updated
Jun 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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