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Completed

NCT Number: NCT02898675

Advantages of Autologous Platelet-Rich Fibrin Membrane on Growth Factor Levels and Periodontal Healing

Platelet rich fibrin is a second generation platelet concentration which contains various growth factors. The aim of this study is to evaluate the clinical and biochemical efficacy of PRF in subjects of chronic periodontitis in the operation of conventional periodontal flap.

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Key information

Conditions

Chronic Periodontitis Chronic Disease Disease Attributes Mouth Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Periodontal Diseases Periodontitis Stomatognathic Diseases

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

PRF was developed in 2001 by Choukroun in France, it was the second generation fibrin adhesive, and was used to accelerate the soft and hard tissue healing. Many studies have shown beneficial effects of PRF on osteoconductive filler material in sinus lift operations, treatment of periodontal sulcus defect and treatment of furcation defects. Also PRF contains many growth factors. PRF accelerates periodontal regeneration through the gradually excreted growth factors and contributes to the bone regeneration. In this study, the investigators evaluated the effect of PRF on growth factors and its contribution to periodontal regeneration in subjects with chronic periodontitis.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with CP who had pocket depth ≤ 5 mm and at least two area (grouped as Control and PRF) with horizontal bone loss after initial treatment

Exclusion criteria

  • The subjects excluded in the study had history of systemic disease, were smokers, had allergy to any drug, had need for prophylaxis of antibiotic and had taken antibiotics at least 6 months

Treatment and study plan

Platelet rich fibrine

Device

Platelet rich fibrin increases the growth factors. So it was applied for treatment of periodontal bone loss.

Open Flap Debridement

Device

Only open flap debridement treatment the bone loss limitedly

Primary outcomes

  1. Level of Growth Factor

    Time frame: 6 weeks

    Change from baseline growth factors levels of GCF at 6 weeks were measured by periopaper

Secondary outcomes

  1. Alteration of Clinical Attachment Level

    Time frame: 9 month

    Change from baseline Clinical Attachment Levels at 9 months were measured with periodontal probe.

  2. Alteration of Periodontal Pocket Depth

    Time frame: 9 month

    Change from baseline Pocket Depth at 9 months were measured with periodontal probe.

Sponsors and collaborators

Lead sponsor

Ataturk University

Other

Registry information

Official study title

Investigation of the Contributions of Platelet Rich Fibrin Combined With Open Flap Debridement on Periodontal Healing

Important dates

Study start
2014
Primary completion
2015
Study completion
2016
First posted
Sep 13, 2016
Registry last updated
Sep 13, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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