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Completed

NCT Number: NCT00613912

Advanced MRI in Major Depression

Depression is the most common psychiatric disorder.

* 3-5% of a given population has major depression. * Less than 50% of the depressed in Denmark are diagnosed with major depression. * 25-50% of the depressed have a relative with major depression-underlying brain pathology?

The purpose of this study is to use MRI to evaluate cerebral morphology and function in ambulant patients with major depression

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Key information

Conditions

Depressive Disorder, Major Depressive Disorder Mental Disorders Mood Disorders

Age range

20 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Aalborg Hospital / Aarhus University Hospital

Aalborg, Jutland, 9000, Denmark

About this study

Previous studies within major depression, have often included hospitalized patients with severe symptoms and imaging have been performed with PET and SPECT, which uses ionizing radiation. This study focus on ambulant patients(with or without medication/ECT treatment), to find patients in an earlier stage. Cerebral perfusion with the MR sequence Arterial Spin Labelling, concentrations of different metabolites with MR spectroscopy and brain volumetry with BRAVO 3D T1 ax will be performed.

MR protocol: T2 sag, T2 FLAIR ax, ASL ax, MRS and 3D T1 ax. Scan time 45 min.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients who fulfil ICD-10´s criteria for major depression, found within the ambulant psychiatric sector and who has a HAM-D ≥ 18

Exclusion criteria

  • If the patient has pacemaker or other magnetic devices
  • Pregnancy
  • Has had an operation in the brain
  • bipolar disorder

Treatment and study plan

Magnetic Resonance Imaging

Other
  • Morphological sequences
  • Arterial Spin Labelling (Perfusion)
  • Spectroscopy: anterior cingulate cortex Naa, Cho, Cr, Myo-inositol, glutamate TE 30 Reference voxel in Parietal white matter

Other names: 3 Tesla GE Scanner HDx

Primary outcomes

  1. Differences in morphological and functional cerebral MRI findings in patients suffering from major depression

    Time frame: 6 months from first MRI in each patient

Sponsors and collaborators

Lead sponsor

University of Aarhus

Other

Registry information

Official study title

Advanced MRI at 3T for the Evaluation of Ambulant Patients With Major Depression

Important dates

Study start
2008
Primary completion
2009
Study completion
2011
First posted
Feb 13, 2008
Registry last updated
Nov 21, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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