Adult Study Oxytocin - Behavioral

Part 2: A supplementary study will be added to the proposed parent study, which includes additional behavioral testing consisting of several social cognition computer tasks, clinical assessments, physiological measurements, and questionnaires. The study will be conducted with the same study arms and study interventions as in the proposed parent study. For this supplementary study, the inclusion criteria has broadened to include patients with bipolar disorder with psychotic features and brief psychotic disorder.

Inclusion criteria

for Patients:

• 18 to 45 years of age
• Clinically stable
• English Speaking
• Meet DSM-5 criteria for schizophrenia, schizophreniform, schizoaffective disorder, bipolar disorder with psychotic features, or brief psychotic disorder
• No or at most only minor changes to medications in the past week
• Able to use nasal spray
• Must be capable of providing informed consent

Inclusion criteria

for healthy volunteers:

• 18 to 45 years of age
• Clinically stable
• English Speaking
• No diagnosis of mental disorder according to DSM-5, not including mild alcohol use disorder or mild cannabis use disorder
• Able to use nasal spray
• Must be capable of providing informed consent

Exclusion criteria

for Patients:

• Active substance and alcohol use disorder in the past month as determined by the DSM-5 criteria, not including cannabis use disorder
• Subjects with atrophic rhinitis, recurrent nose bleeds, severe brain trauma, and cranial-surgical procedures (hypophysectomy)
• Medical conditions like congestion or sinus problems that could interfere with the study as per the opinion of the investigator
• Hearing deficits
• Pregnancy
• Severe brain trauma

Exclusion criteria

for Healthy Controls:

• Active substance and moderate/severe alcohol use disorder, or mood disorder in the past month as determined by the DSM-5 criteria, not including mild alcohol use disorder or mild cannabis use disorder
• Meet for a current psychiatric disorder according to DSM-5 criteria
• Subjects with atrophic rhinitis, recurrent nose bleeds, severe brain trauma, and cranial-surgical procedures (hypophysectomy)
• Medical conditions like congestion or sinus problems that could interfere with the study as per the opinion of the investigator
• Hearing deficits
• Pregnancy
• Severe brain trauma