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NCT Number: NCT02419274

Adult Arm of DZL All Age Asthma Cohort (ALLIANCE)

Deep Phenotyping of adult asthma patients:

* severity from mild to severe * both atopic and non-atopic * both childhood and adult onset * both smokers and non-smokers * corresponding pediatric cohort (Pediatric Arm of DZL All Age Asthma Cohort) with equivalent SOPs regarding collection of biomaterial and clinical data incl. lung function, further processing of biomaterial and further analyses

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Key information

Conditions

Asthma Bronchial Diseases Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Lung Diseases Lung Diseases, Obstructive Respiratory Hypersensitivity Respiratory Tract Diseases

Age range

18 year–99 year

Sex eligibility

All sexes

Study type

Observational

Primary location

About this study

The clinical heterogeneity of asthma patients has been increasingly recognised within the last years. Recent studies and articles highlighted the idea of asthma not beeing a single disease but rather a unifying term for multiple phenotypes. Phenotype in this sense is defined as the combination of observable properties of an organism, that are produced by the interactions of a genotype and the environment. In contrast, endotype describes a specific underlying pathophysiological pathway. Linking asthma phenotypes and endotypes in a system biological approach is an important research goal in order to develop targeted therapy, especially for severe asthma.

The advantage the investigators' cohort provides is the collaboration with an equivalent pediatric cohort. In this setting questions regarding disease onset, exacerbation and chronicity can be posed and worked with in a comprehensive manner.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Proven Diagnosis according to current GINA Guideline (2014)
  • Ability to read and understand German
  • Ability to understand and agree to informed consent

Exclusion criteria

  • History of respiratory tract infection within the last 4 weeks before inclusion

Treatment and study plan

Primary outcomes

  1. Defining clinical asthma phenotypes by combining clinical, lung function and biomaterial data

    Time frame: 2 years

Study contacts

Contact information is provided by the study sponsor or research team.

Joern Bullwinkel, PhD

CONTACT

[email protected]

+49 4102 601 2410

Thomas J Bahmer, MD

CONTACT

[email protected]

+49 4102 601 2412

Sponsors and collaborators

Lead sponsor

LungenClinic Grosshansdorf

Other

Collaborators

  • German Center for Lung Research
  • Research Center Borstel

Registry information

Official study title

The All Age Asthma Cohort (ALLIANCE) of the German Center for Lung Research (DZL), Adult Arm

Acronym: ALLIANCE

Important dates

Study start
2014
Primary completion
2025
Study completion
2030
First posted
Apr 17, 2015
Registry last updated
Oct 12, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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